Institute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany; JARA - Translational Brain Medicine & INM-11, RWTH Aachen University, 52074 Aachen, Germany; Department of Neurology, University Clinic Aachen, 52074 Aachen, Germany.
Institute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Front Neuroendocrinol. 2019 Jan;52:79-112. doi: 10.1016/j.yfrne.2018.10.001. Epub 2018 Oct 28.
Due to its increasing prevalence, Type 2 diabetes mellitus (T2DM) represents a major health challenge for modern society. Despite it being of fundamental interest, only a few MRI studies have conducted statistical analyses to draw scientifically valid conclusions about the complex interplay of T2DM and its associated clinical, structural, functional, metabolite, as well as cognitive distortions. Therefore, a systematic review of 68 manuscripts, following the PRISMA guidelines, was conducted. Notably, although the associations between imaging, clinical, and cognitive variables are not fully homogeneous, findings show a clear trend towards a link between altered brain structure and a decline in cognitive processing ability. The results of the review highlight the heterogeneity of the methods used across manuscripts in terms of assessed clinical variables, imaging, and data analysis methods. This is particularly significant as, if the subjects' criteria are not carefully considered, results are easily prone to confounding factors.
由于其患病率不断增加，2 型糖尿病（T2DM）是现代社会面临的主要健康挑战。尽管这是一个非常重要的问题，但只有少数 MRI 研究进行了统计分析，以得出关于 T2DM 及其相关临床、结构、功能、代谢以及认知扭曲之间复杂相互作用的科学有效结论。因此，按照 PRISMA 指南对 68 篇论文进行了系统综述。值得注意的是，尽管影像学、临床和认知变量之间的关联并非完全一致，但研究结果表明，大脑结构改变与认知处理能力下降之间存在明显的关联趋势。该综述的结果突出了文献中评估的临床变量、影像学和数据分析方法在使用方法上的异质性。这一点非常重要，因为如果不仔细考虑研究对象的标准，结果很容易受到混杂因素的影响。
