Litwiniuk-Kosmala Małgorzata, Makuszewska Maria, Czesak Małgorzata
Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Warsaw, Poland.
Front Med (Lausanne). 2023 Feb 10;10:1115212. doi: 10.3389/fmed.2023.1115212. eCollection 2023.
Tumors of the head and neck region form a heterogeneous group of pathologies, including various benign lesions and malignant neoplasms. Endoglin, also known as CD105, is an accessory receptor for transforming growth factor beta (TGF-β), that regulates angiogenesis, both under physiological and pathological conditions. It is highly expressed in proliferating endothelial cells. Therefore, it is considered as a marker of tumor-related angiogenesis. In this review we discuss the role of endoglin as a possible marker of carcinogenesis, as well as a potential target for antibody-based therapies in the neoplasms of the head and neck region.
头颈部区域的肿瘤构成了一组异质性的病理疾病，包括各种良性病变和恶性肿瘤。内皮糖蛋白，也称为CD105，是转化生长因子β（TGF-β）的辅助受体，在生理和病理条件下均调节血管生成。它在增殖的内皮细胞中高度表达。因此，它被认为是肿瘤相关血管生成的标志物。在本综述中，我们讨论了内皮糖蛋白作为致癌作用可能标志物的作用，以及作为头颈部区域肿瘤基于抗体治疗的潜在靶点。
