头颈部鳞状细胞癌中微血管密度的预后价值：Meta 分析。
Prognostic Value of Microvessel Density in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis.
机构信息
Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Dis Markers. 2020 Sep 28;2020:8842795. doi: 10.1155/2020/8842795. eCollection 2020.
The prognostic value of microvessel density (MVD) in head and neck squamous cell carcinoma (HNSCC) remains disputable. The purpose of this study was to comprehensively determine the prognostic value of MVD in HNSCC. Relevant literatures were identified using PubMed, Embase, and Cochrane Library. A meta-analysis was performed to clarify the prognostic role of MVD in HNSCC patients and different subgroups. A total of 14 eligible articles were included in this meta-analysis. The combined hazard ratio (HR) and 95% confidence interval (95% CI) for overall survival (OS) of 11 studies was 1.663 (1.236-2.237, = 0.001), and the pooled HR and 95% CI for progression-free survival (PFS) of 7 studies was 2.069 (1.281-3.343, = 0.003). Subgroup analyses were also performed on different issues, such as regional distribution of patients, age, tumor location, antibody, and treatment strategy. To conclude, high MVD is associated with worse OS and PFS in patients with HNSCC.
微血管密度 (MVD) 在头颈部鳞状细胞癌 (HNSCC) 中的预后价值仍存在争议。本研究旨在全面确定 MVD 在 HNSCC 患者中的预后价值。使用 PubMed、Embase 和 Cochrane Library 确定相关文献。进行荟萃分析以阐明 MVD 在 HNSCC 患者和不同亚组中的预后作用。这项荟萃分析共纳入了 14 项符合条件的文章。11 项研究中总生存期 (OS) 的合并风险比 (HR) 和 95%置信区间 (95%CI) 为 1.663 (1.236-2.237， = 0.001)，7 项研究中无进展生存期 (PFS) 的合并 HR 和 95%CI 为 2.069 (1.281-3.343， = 0.003)。还针对患者的区域分布、年龄、肿瘤位置、抗体和治疗策略等不同问题进行了亚组分析。总之，高 MVD 与 HNSCC 患者的 OS 和 PFS 较差相关。
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