Jing Wangwei, Huang Shushi, Xiang Pingping, Huang Jiniu, Yu Hong
Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Cardiovasc Med. 2023 Feb 9;10:1061119. doi: 10.3389/fcvm.2023.1061119. eCollection 2023.
The Dietary precursor has been identified as a contributor in the development of cardiovascular disease. However, it is inconsistent if dietary precursors could affect the process of cardiovascular disease.
Here we performed Mendelian randomization (MR) analysis of the data from genome-wide association study of European ancestry to evaluate the independent effects of three dietary precursors on cardiovascular disease (CVD), myocardial infarction (MI), heart failure (HF), atrial fibrillation (AF), and valvular disease (VHD). Inverse variance weighting method was used for the MR estimation. Sensitivity was determined by MR-PRESSO analysis, weighted median analysis, MR-Egger analysis, and Leave-one-out analysis.
We found that elevated choline level had a causal relationship with VHD [odds ratio (OR) = 1.087, 95% confidence interval (CI), 1.003-1.178, = 0.041] and MI (OR = 1.250, 95% CI, 1.041-1.501, = 0.017) by single-variable MR analysis. Furthermore, elevated carnitine level was associated with MI (OR = 5.007, 95% CI, 1.693-14.808, = 0.004) and HF (OR = 2.176, 95% CI, 1.252-3.780, = 0.006) risk. In addition, elevated phosphatidylcholine level can increase the risk of MI (OR = 1.197, 95% CI, 1.026-1.397, = 0.022).
Our data show that choline increases VHD or MI risk, carnitine increases the risk of MI or HF, and phosphatidylcholine increases HF risk. These findings suggest the possibility that decrease in choline level in circulation may be able to reduce overall VHD or MI risk, reduce in carnitine level could be decrease MI and HF risks as well as decrease in phosphatidylcholine could reduce MI risk.
膳食前体已被确定为心血管疾病发展的一个促成因素。然而，膳食前体是否会影响心血管疾病的进程尚无定论。
在此，我们对欧洲血统全基因组关联研究的数据进行孟德尔随机化（MR）分析，以评估三种膳食前体对心血管疾病（CVD）、心肌梗死（MI）、心力衰竭（HF）、心房颤动（AF）和瓣膜病（VHD）的独立影响。MR估计采用逆方差加权法。通过MR-PRESSO分析、加权中位数分析、MR-Egger分析和留一法分析确定敏感性。
单变量MR分析发现，胆碱水平升高与VHD[比值比（OR）=1.087，95%置信区间（CI），1.003-1.178，P=0.041]和MI（OR=1.250，95%CI，1.041-1.501，P=0.017）存在因果关系。此外，肉碱水平升高与MI（OR=5.007，95%CI，1.693-14.808，P=0.004）和HF（OR=2.176，95%CI，1.252-3.780，P=0.006）风险相关。此外，磷脂酰胆碱水平升高会增加MI风险（OR=1.197，95%CI，1.026-1.397，P=0.022）。
我们的数据表明，胆碱会增加VHD或MI风险，肉碱会增加MI或HF风险，磷脂酰胆碱会增加HF风险。这些发现提示，循环中胆碱水平降低可能能够降低总体VHD或MI风险，肉碱水平降低可能会降低MI和HF风险，磷脂酰胆碱水平降低可能会降低MI风险。
