Lutz J, Stark M
Physiologisches Institut der Universität Würzburg, Federal Republic of Germany.
Pflugers Arch. 1987 Sep;410(1-2):181-4. doi: 10.1007/BF00581913.
The decline of the concentration of perfluorochemicals (PFC) after a single injection of three different doses was studied in the circulation of rats. The doses used amounted to 4.4, 10 and 14 g/kg body weight of Fluosol-DA, an emulsion of 7 parts of perfluorodecalin (FDC) and 3 parts of perfluorotripropylamine (FTPA). This also allowed testing of the composition of the emulsion remaining in the circulation and of that found in the liver. After two days a decrease of the half life from 34.0 +/- 0.7 to 17.1 +/- 4.3 h was found within the circulation at the highest dose. At the same time a change in the composition of the emulsion in the blood stream occurred, favouring the fraction of FTPA. FTPA increased from 28.3 +/- 1.4 to 54.4 +/- 8.1% on the fourth day. Whereas in the cells of the liver PFC droplets may be broken up, freed from their surfactant layer and handled according to their individual components, for PFC in the blood stream an unchanged composition should be assumed. Both results, the decreasing half life and the change in composition of the circulating emulsion may best be explained by a shrinking and instability of the emulgator film, showing the necessity for development of a superior surfactant.
在大鼠循环系统中研究了单次注射三种不同剂量的全氟化合物（PFC）后其浓度的下降情况。所用剂量相当于按体重计4.4、10和14 g/kg的氟碳乳剂（Fluosol-DA），该乳剂由7份全氟萘烷（FDC）和3份全氟三丙胺（FTPA）组成。这也使得能够对循环系统中残留的乳剂成分以及在肝脏中发现的乳剂成分进行检测。在最高剂量下，两天后循环系统中的半衰期从34.0±0.7小时降至17.1±4.3小时。同时，血流中乳剂的成分发生了变化，有利于FTPA部分。在第四天，FTPA从28.3±1.4%增加到54.4±8.1%。虽然肝脏细胞中的PFC液滴可能会被分解，从其表面活性剂层中释放出来，并根据其各自的成分进行处理，但对于血流中的PFC，应假定其成分不变。半衰期的缩短和循环乳剂成分的变化这两个结果，最好用乳化剂膜的收缩和不稳定性来解释，这表明开发一种更优质的表面活性剂很有必要。
