Department of Radiation Oncology, Peking University Third Hospital, Beijing, China.
Front Immunol. 2023 Feb 9;14:1113312. doi: 10.3389/fimmu.2023.1113312. eCollection 2023.
Recent studies have revealed that tumor-associated macrophages are the most abundant stromal cells in the tumor microenvironment and play an important role in tumor initiation and progression. Furthermore, the proportion of macrophages in the tumor microenvironment is associated with the prognosis of patients with cancer. Tumor-associated macrophages can polarize into anti-tumorigenic phenotype (M1) and pro-tumorigenic phenotype (M2) by the stimulation of T-helper 1 and T-helper 2 cells respectively, and then exert opposite effects on tumor progression. Besides, there also is wide communication between tumor-associated macrophages and other immune compositions, such as cytotoxic T cells, regulatory T cells, cancer-associated fibroblasts, neutrophils and so on. Furthermore, the crosstalk between tumor-associated macrophages and other immune cells greatly influences tumor development and treatment outcomes. Notably, many functional molecules and signaling pathways have been found to participate in the interactions between tumor-associated macrophages and other immune cells and can be targeted to regulate tumor progression. Therefore, regulating these interactions and CAR-M therapy are considered to be novel immunotherapeutic pathways for the treatment of malignant tumors. In this review, we summarized the interactions between tumor-associated macrophages and other immune compositions in the tumor microenvironment and the underlying molecular mechanisms and analyzed the possibility to block or eradicate cancer by regulating tumor-associated macrophage-related tumor immune microenvironment.
最近的研究表明，肿瘤相关巨噬细胞是肿瘤微环境中最丰富的基质细胞，在肿瘤的发生和发展中发挥着重要作用。此外，肿瘤微环境中巨噬细胞的比例与癌症患者的预后相关。肿瘤相关巨噬细胞可分别被辅助性 T 细胞 1 和辅助性 T 细胞 2 刺激极化为抗肿瘤表型（M1）和促肿瘤表型（M2），然后对肿瘤进展产生相反的影响。此外，肿瘤相关巨噬细胞与其他免疫成分（如细胞毒性 T 细胞、调节性 T 细胞、癌相关成纤维细胞、中性粒细胞等）之间也存在广泛的通信。此外，肿瘤相关巨噬细胞与其他免疫细胞之间的串扰极大地影响着肿瘤的发展和治疗效果。值得注意的是，许多功能分子和信号通路被发现参与了肿瘤相关巨噬细胞与其他免疫细胞之间的相互作用，并可作为靶点来调节肿瘤进展。因此，调节这些相互作用和 CAR-M 治疗被认为是治疗恶性肿瘤的新的免疫治疗途径。在这篇综述中，我们总结了肿瘤微环境中肿瘤相关巨噬细胞与其他免疫成分之间的相互作用及其潜在的分子机制，并分析了通过调节肿瘤相关巨噬细胞相关肿瘤免疫微环境来阻断或消除癌症的可能性。
