Xiao Man, Li Xiaoduan
Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Immunol. 2025 May 16;16:1572764. doi: 10.3389/fimmu.2025.1572764. eCollection 2025.
The tumor microenvironment (TME), which has crucial roles in tumor progression, metastasis, and drug resistance, contains abundant immune cells. The most influential of these include tumor-associated macrophages (TAMs), which both secrete microenvironment-modifying cytokines and are acted upon by various other components of the microenvironment. The heterogeneity and diversity of TAMs are closely associated with patients' response to tumor immunotherapy; thus, therapeutic targeting of TAMs has become a research focus in recent years. Although numerous studies have explored how TAMs alter the microenvironment, relatively few have investigated the impact of the microenvironment on TAMs. In this review, we discuss the effects of various components of the tumor microenvironment on TAMs from the perspectives of recruitment, reprogramming, and functional modulation, with a focus on the cellular components of the microenvironment. We also summarize the development of immunotherapies targeting TAMs, which have shown promising results in clinical trials.
肿瘤微环境（TME）在肿瘤进展、转移和耐药性方面发挥着关键作用，其中含有丰富的免疫细胞。其中最具影响力的包括肿瘤相关巨噬细胞（TAM），它既分泌可改变微环境的细胞因子，又受到微环境中其他各种成分的作用。TAM的异质性和多样性与患者对肿瘤免疫治疗的反应密切相关；因此，针对TAM的治疗靶向已成为近年来的研究热点。尽管众多研究探讨了TAM如何改变微环境，但相对较少有研究调查微环境对TAM的影响。在本综述中，我们从招募、重编程和功能调节的角度讨论肿瘤微环境的各种成分对TAM的影响，重点关注微环境的细胞成分。我们还总结了针对TAM的免疫疗法的发展情况，这些疗法在临床试验中已显示出有前景的结果。
