Momayez Sanat Zahra, Mohammadi Ganjaroudi Negar, Pirsalehi Ali
Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clin Med Insights Case Rep. 2023 Feb 8;16:11795476231153279. doi: 10.1177/11795476231153279. eCollection 2023.
Bupropion is a dopamine reuptake inhibitor, which is prescribed as an effective drug for the treatment of depression and as a complementary drug for smoking cessation in more than 50 countries. Although constipation and nausea are known as side effects of Bupropion, gastric ulcer has not been previously reported.
In this case report a 28-year-old woman presented with a gastric ulcer 8 months after beginning depression treatment with Bupropion 150 mg once daily. Pantoprazole and Famotidine were prescribed to the patient. However, the gastric ulcer did not heal. After discontinuation of Bupropion, the gastric ulcer was treated.
The present case report suggests that Bupropion may lead to peptic ulcers or this drug interferes with the treatment of gastric ulcers.
安非他酮是一种多巴胺再摄取抑制剂，在50多个国家被用作治疗抑郁症的有效药物以及戒烟的辅助药物。虽然便秘和恶心是安非他酮已知的副作用，但此前尚未有胃溃疡的报道。
在本病例报告中，一名28岁女性在开始每日一次服用150毫克安非他酮治疗抑郁症8个月后出现胃溃疡。患者服用了泮托拉唑和法莫替丁。然而，胃溃疡并未愈合。停用安非他酮后，胃溃疡得到了治疗。
本病例报告表明，安非他酮可能导致消化性溃疡，或者这种药物会干扰胃溃疡的治疗。
