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大龄儿童的B型(b型流感嗜血杆菌)脑膜炎:关于一例病例

[ type B (Hib) meningitis in older children: about a case].

作者信息

Trabelsi Ines, Ali Mouadh Ben, Romdhane Manel Ben, Smaoui Hanen, Hadj Imen Bel, Boussetta Khadija

机构信息

Service de Médecine Infantile B, Hôpital d'Enfants « Béchir Hamza » de Tunis, Tunis, Tunisie.

Service de Microbiologie, Hôpital d´Enfants de Tunis, Tunis, Tunisie.

出版信息

Pan Afr Med J. 2022 Jul 20;42:220. doi: 10.11604/pamj.2022.42.220.35804. eCollection 2022.

Abstract

Since widespread vaccination, invasive Haemophilus influenzae type b (Hib) has become a rare infection. We here report the case of a 9-year-old boy admitted with seizures associated with fever and impaired general condition. First examination showed comatose child, Glasgow score 9/15, fever 38.2, deep tendon reflexes without frank meningeal syndrome. Laboratory tests showed polymorphonuclear neutrophils (PNN) with CRP 45.8. Cerebrospinal fluid (CSF) analysis revealed a cloudy appearance, pleiocytosis (6760 white blood cell count/ mm) with neutrophil predominance (PNN = 90%, lymphocytes = 10%). Direct examination showed polymorphic bacilli, soluble antigen of Haemophilus influenzae type b, decreased glycorachy 0.04 mmol/L and hyper proteinorachie 4.097 g/L. MRI of the cerebellomedullary fissure revealed subtentorial and supratentorial encephalitis with bilateral parieto-occipital and cerebellar cortical and subcortical signal anomalies. The patient was treated with cefotaxime with favorable outcome. The patient had not been vaccinated against Hib in early childhood. After a 3-year follow-up, the patient was asymptomatic with no neurosensory sequelae. In subjects with severe Hib infection proof of vaccination or testing for underlying immunodeficiency are required.

摘要

自广泛接种疫苗以来,侵袭性b型流感嗜血杆菌(Hib)感染已变得罕见。我们在此报告一例9岁男孩病例,该男孩因发热及全身状况不佳伴癫痫发作入院。首次检查显示患儿昏迷,格拉斯哥评分为9/15,体温38.2℃,深腱反射存在但无明显脑膜刺激征。实验室检查显示多形核中性粒细胞(PNN)升高,C反应蛋白(CRP)为45.8。脑脊液(CSF)分析显示外观浑浊,细胞增多(白细胞计数6760/mm),以中性粒细胞为主(PNN = 90%,淋巴细胞 = 10%)。直接检查显示多形杆菌、b型流感嗜血杆菌可溶性抗原、脑脊液葡萄糖降低至0.04 mmol/L以及蛋白升高至4.097 g/L。小脑延髓裂的磁共振成像(MRI)显示幕下和幕上脑炎,双侧顶枕叶及小脑皮质和皮质下信号异常。患者接受头孢噻肟治疗,预后良好。该患者在幼儿期未接种过Hib疫苗。经过3年随访,患者无症状,无神经感觉后遗症。对于严重Hib感染患者,需要有疫苗接种证明或进行潜在免疫缺陷检测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aa5/9949271/684a855538cb/PAMJ-42-220-g001.jpg

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