Lv Zhexi, Lv Zekai, Song Linjiang, Zhang Qinxiu, Zhu Shaomi
School of Medical and Life Sciences/Affiliated Reproductive and Women-Children Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
Front Genet. 2023 Feb 8;14:1056061. doi: 10.3389/fgene.2023.1056061. eCollection 2023.
Decreased ovarian reserve (DOR) is defined as a decrease in the quality and quantity of oocytes, which reduces ovarian endocrine function and female fertility. The impaired follicular development and accelerated follicle atresia lead to a decrease in the number of follicles, while the decline of oocyte quality is related to the disorder of DNA damage-repair, oxidative stress, and the dysfunction of mitochondria. Although the mechanism of DOR is still unclear, recent studies have found that long non-coding RNA (lncRNA) as a group of functional RNA molecules participate in the regulation of ovarian function, especially in the differentiation, proliferation and apoptosis of granulosa cells in the ovary. LncRNAs participate in the occurrence of DOR by affecting follicular development and atresia, the synthesis and secretion of ovarian hormones. This review summarizes current research on lncRNAs associated with DOR and reveals the potential underlying mechanisms. The present study suggests that lncRNAs could be considered as prognostic markers and treatment targets for DOR.
卵巢储备功能下降（DOR）被定义为卵母细胞的质量和数量减少，这会降低卵巢内分泌功能和女性生育能力。卵泡发育受损和卵泡闭锁加速导致卵泡数量减少，而卵母细胞质量下降与DNA损伤修复紊乱、氧化应激和线粒体功能障碍有关。尽管DOR的机制仍不清楚，但最近的研究发现，长链非编码RNA（lncRNA）作为一组功能性RNA分子参与卵巢功能的调节，特别是在卵巢颗粒细胞的分化、增殖和凋亡过程中。lncRNAs通过影响卵泡发育和闭锁、卵巢激素的合成和分泌参与DOR的发生。本综述总结了目前关于与DOR相关的lncRNAs的研究，并揭示了潜在的机制。本研究表明，lncRNAs可被视为DOR的预后标志物和治疗靶点。
