Thrombosis, Hemostasis and Atherogenesis Research Unit, H.G.R. No. 1 Dr. "Carlos Mac Gregor Sánchez Navarro", Mexican Social Security Institute, México City, Mexico.
Health Research Division, Highly Specialized Medical Unit of Traumatology, Orthopedics and Rehabilitation "Dr. Victorio de la Fuente Narváez", Mexican Social Security Institute, Mexico City, Mexico.
J Renin Angiotensin Aldosterone Syst. 2023 Feb 17;2023:4944238. doi: 10.1155/2023/4944238. eCollection 2023.
Essential hypertension is the result of modifiable and genetic factors, and it is associated with increased risk for atherothrombosis. Some polymorphisms are associated with hypertensive disease. The objective was to analyze the association between eNOS Glu298Asp, MTHR C677T, AGT M235T, AGT T174M, and A1166C and ACE I/D polymorphisms with essential hypertension in the Mexican population.
In the present study, 224 patients with essential hypertension and 208 subjects without hypertension were included. The Glu298Asp, C677T, M235T, T174M, A1166C, and I/D polymorphisms were determined by the PCR-RFLP technique.
We found statistical differences in age, gender, BMI, systolic and diastolic blood pressure, and total cholesterol between control and cases. However, we found no significant differences in HbA1c and triglycerides between both groups. We observed statistical significant differences in the genotype distribution of Glu298Asp ( = 0.001), I/D ( = 0.02), and M235T ( = 0.004) polymorphisms between both groups. In contrast, there were no differences related to distribution of genotypes of MTHFR C677T ( = 0.12), M174T ( = 0.46), and A1166C ( = 0.85) between cases and control groups.
We identified that Glu298Asp, I/D, and M234T polymorphisms represented an increased risk for essential hypertension and those genetic variants could contribute to the presence of endothelial dysfunction and vasopressor effect, hyperplasia, and hypertrophy of smooth muscle cells, which had an impact for hypertension. In contrast, we found no association between C677C, M174T, and A1166C polymorphisms and hypertensive disease. We suggested that those genetic variants could be identified in individuals with high risk to avoid hypertension and thrombotic disease.
原发性高血压是可改变和遗传因素的结果，与动脉血栓形成的风险增加有关。一些多态性与高血压疾病有关。目的是分析 eNOS Glu298Asp、MTHR C677T、AGT M235T、AGT T174M 和 A1166C 与 ACE I/D 多态性与墨西哥人群原发性高血压的关系。
本研究纳入 224 例原发性高血压患者和 208 例无高血压患者。采用 PCR-RFLP 技术检测 Glu298Asp、C677T、M235T、T174M、A1166C 和 I/D 多态性。
我们发现对照组和病例组在年龄、性别、BMI、收缩压和舒张压以及总胆固醇方面存在统计学差异。然而，两组间 HbA1c 和三酰甘油无显著差异。我们观察到两组间 Glu298Asp（ = 0.001）、I/D（ = 0.02）和 M235T（ = 0.004）多态性的基因型分布存在统计学显著差异。相比之下，病例组和对照组之间 MTHFR C677T（ = 0.12）、M174T（ = 0.46）和 A1166C（ = 0.85）的基因型分布无差异。
我们发现 Glu298Asp、I/D 和 M234T 多态性增加了原发性高血压的风险，这些遗传变异可能导致内皮功能障碍和升压作用、平滑肌细胞增生和肥大，从而影响高血压。相反，我们发现 C677C、M174T 和 A1166C 多态性与高血压疾病无关。我们认为，在高危人群中可以识别这些遗传变异，以避免高血压和血栓性疾病。
