Isordia-Salas Irma, Alvarado-Moreno José A, Jiménez-Alvarado Rosa M, Hernández-Juárez Jesús, Santiago-Germán David, Leaños-Miranda Alfredo, Majluf-Cruz Abraham
Medical Research Unit in Thrombosis, Hemostasis and Atherogenesis, H.G.R. No 1 'Dr Carlos Mac Gregor Sánchez Navarro' Mexican Institute of Social Security.
Hematology Department, CMN 20 Noviembre, Institute of Security and Social Services for State Workers.
Blood Coagul Fibrinolysis. 2018 Apr;29(3):267-274. doi: 10.1097/MBC.0000000000000714.
: The renin-angiotensin system plays an important role in the regulation of blood pressure and the development of coronary artery disease. The aim was to examine the association of the insertion deletion in the angiotensin-converting enzyme gene, M235T and T174M polymorphisms in the angiotensinogen gene with ST elevation acute myocardial infarction (STEAMI) in young Mexican population. We analyzed 242 unrelated patients with STEAMI 45 or less years of age, admitted to a cardiovascular intense care unit, and 242 individuals without STEAMI matched by age and sex, recruited from January 2006 and June 2013. The polymorphisms insertion deletion, M235T and T174M were determined in all participants by a polymerase chain-reaction-restriction fragment length polymorphism assay. There was a significant difference in the insertion deletion genotype distribution between two groups (P = 0.03) and a higher percentage of the T allele M235T polymorphism in the group of STEAMI patients (P = 0.02). The T174M polymorphism was not associated (P = 0.08). The insertion deletion and M235T polymorphisms, smoking, hypertension, familial history of cardiovascular disease and dyslipidemia were independent risk factors for STEAMI. Our results identified that the D allele from the insertion deletion and M235T but not T174M polymorphisms represent an independent risk factor for STEAMI in young Mexican population.
肾素-血管紧张素系统在血压调节和冠状动脉疾病发展中起重要作用。目的是研究血管紧张素转换酶基因插入缺失、血管紧张素原基因M235T和T174M多态性与墨西哥年轻人群ST段抬高型急性心肌梗死（STEAMI）的相关性。我们分析了2006年1月至2013年6月期间收治入心血管重症监护病房的242例年龄在45岁及以下的非亲缘关系STEAMI患者，以及242例年龄和性别匹配的非STEAMI个体。通过聚合酶链反应-限制性片段长度多态性分析测定所有参与者的插入缺失、M235T和T174M多态性。两组间插入缺失基因型分布存在显著差异（P = 0.03），STEAMI患者组中T等位基因M235T多态性的比例更高（P = 0.02）。T174M多态性无相关性（P = 0.08）。插入缺失和M235T多态性、吸烟、高血压、心血管疾病家族史和血脂异常是STEAMI的独立危险因素。我们的结果表明，插入缺失和M235T多态性中的D等位基因而非T174M多态性是墨西哥年轻人群STEAMI的独立危险因素。
