Qamar Mohammad A, Kogut Lucas M, Tebha Sameer S, Arif Aabiya, Ninmol Jesse, Abdul Razzaque Muhammad R, Qamar Khulud, Yosufi Abubakr
Ziauddin University.
Department of Nephrology, Hope Medical Institute, Newport News, Virginia, USA.
Ann Med Surg (Lond). 2023 Feb 7;85(2):92-101. doi: 10.1097/MS9.0000000000000107. eCollection 2023 Feb.
The renal system manifestations of coronavirus disease-2019 have been documented extensively; however, scientific literature remains scarce regarding collapsing glomerulopathy hence the need for this investigation.
A comprehensive review was conducted covering a timeline from 1 January 2020 to 5 February 2022 without any restrictions. The data extraction was conducted independently, and articles were assessed for the risk of bias. Data analysis was conducted using Comprehensive Meta-Analysis version 3.3.070 and RevMan version 5.4 for pooled proportions and risk ratio (RR) between dialysis-dependent and independent treatment groups with a -value less than 0.05 considered significant.
A total of 38 studies were included in this review, including 74 (65.9%) males. The mean age was 54.2 years old. The most common symptoms reported were related to the respiratory system (59.6%, 95% CI: 50.4-68.2%) and hematuria (34.2%, 95% CI: 26.1-43.4). Antibiotics (25.9%, 95% CI: 12.9-45.3%) was the commonest management used. Proteinuria was the most reported laboratory finding at 89.5% (95% CI: 82.4-93.9%), while the commonest microscopic finding was acute tubular injury (77.2%, 95% CI: 68.6-84.0%). An increased risk of the presence of symptoms (0.005) and microscopic findings (0.0003) related to collapsing glomerulopathy in dialysis-dependent group was noted with increased management (0.01) used in this group for coronavirus disease-2019 infection.
The findings of this study portray the prognostic value of the variables (symptoms and microscopic findings, etc.) reported in the analysis. Hence this study serves as a foundation for future investigations that minimize the study's limitations to provide a more robust conclusion.
2019冠状病毒病的肾脏系统表现已有广泛记录；然而，关于塌陷性肾小球病的科学文献仍然稀少，因此需要进行这项调查。
进行了一项全面综述，涵盖2020年1月1日至2022年2月5日的时间段，无任何限制。数据提取独立进行，并评估文章的偏倚风险。使用综合荟萃分析3.3.070版和RevMan 5.4版进行数据分析，以得出透析依赖组和非透析依赖组之间的合并比例和风险比（RR），P值小于0.05被视为具有统计学意义。
本综述共纳入38项研究，其中男性74例（65.9%）。平均年龄为54.2岁。报告的最常见症状与呼吸系统有关（59.6%，95%CI：50.4 - 68.2%）和血尿（34.2%，95%CI：26.1 - 43.4%）。抗生素（25.9%，95%CI：12.9 - 45.3%）是最常用的治疗方法。蛋白尿是报告最多的实验室检查结果，为89.5%（95%CI：82.4 - 93.9%），而最常见的显微镜检查结果是急性肾小管损伤（77.2%，95%CI：68.6 - 84.0%）。在透析依赖组中，随着对2019冠状病毒病感染治疗措施的增加（0.01），与塌陷性肾小球病相关的症状（0.005）和显微镜检查结果（0.0003）出现的风险增加。
本研究结果描绘了分析中报告的变量（症状和显微镜检查结果等）的预后价值。因此，本研究为未来的研究奠定了基础，这些研究将尽量减少本研究的局限性，以得出更可靠的结论。
