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作为坏死性筋膜炎的一个新兴病因。

as an emerging cause of necrotizing fasciitis.

作者信息

Anthony Nathan, Douthit Nathan T, Foster Allen

机构信息

Edward Via College of Osteopathic Medicine-Auburn Campus in Auburn, AL, 910 S Donahue Dr, Auburn, AL 36832, United States of America.

East Alabama Medical Center Internal Medicine Residency Core Faculty, 2000 Pepperell Pkwy, Opelika, AL 36801, United States of America.

出版信息

IDCases. 2023 Feb 12;31:e01712. doi: 10.1016/j.idcr.2023.e01712. eCollection 2023.

Abstract

Necrotizing fasciitis is a type of necrotizing soft tissue infection (NSTI) that can be polymicrobial or monomicrobial in origin. Polymicrobial infections typically involve anaerobes of the Clostridium or Bacteroides family. This case report highlights necrotizing fasciitis caused by an unusual culprit, , which is a gram-positive anaerobic filamentous bacillus that has only been documented in one prior report to cause NSTI. Currently, about half of the hospitals in the United States are equipped to perform antibiotic susceptibility testing for anaerobes, but less than one-quarter of hospitals actually utilize these tests routinely. Thus, it is common for polymicrobial actinomycoses to be blindly treated with antibiotics that are beta-lactamase resistant and active against anaerobes, such as with piperacillin-tazobactam. Here we examine the potential impact of this lack of testing, as well as the evolution of to cause necrotizing fasciitis.

摘要

坏死性筋膜炎是一种坏死性软组织感染(NSTI),其病因可能是多种微生物感染或单一微生物感染。多种微生物感染通常涉及梭菌属或拟杆菌属的厌氧菌。本病例报告重点介绍了由一种不常见病原体引起的坏死性筋膜炎,该病原体是一种革兰氏阳性厌氧丝状杆菌,此前仅有一份报告记载其可导致NSTI。目前,美国约有一半的医院具备进行厌氧菌抗生素敏感性测试的能力,但实际常规使用这些测试的医院不到四分之一。因此,对于多种微生物引起的放线菌病,通常会盲目使用对β-内酰胺酶耐药且对厌氧菌有效的抗生素进行治疗,如哌拉西林-他唑巴坦。在此,我们探讨了这种缺乏测试的潜在影响,以及该病原体导致坏死性筋膜炎的演变情况。

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