Vu Chau, Xu Botian, González-Zacarías Clio, Shen Jian, Baas Koen P A, Choi Soyoung, Nederveen Aart J, Wood John C
Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.
Division of Cardiology, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States.
Front Physiol. 2023 Feb 9;14:1102983. doi: 10.3389/fphys.2023.1102983. eCollection 2023.
Deoxygenation-based dynamic susceptibility contrast (dDSC) has previously leveraged respiratory challenges to modulate blood oxygen content as an endogenous source of contrast alternative to gadolinium injection in perfusion-weighted MRI. This work proposed the use of sinusoidal modulation of end-tidal CO pressures ( ), which has previously been used to measure cerebrovascular reactivity, to induce susceptibility-weighted gradient-echo signal loss to measure brain perfusion. was performed in 10 healthy volunteers (age 37 ± 11, 60% female), and tracer kinetics model was applied in the frequency domain to calculate cerebral blood flow, cerebral blood volume, mean transit time, and temporal delay. These perfusion estimates were compared against reference techniques, including gadolinium-based DSC, arterial spin labeling, and phase contrast. Our results showed regional agreement between and the clinical comparators. was able to generate robust CVR maps in conjunction to baseline perfusion estimates. Overall, this work demonstrated feasibility of using sinusoidal CO respiratory paradigm to simultaneously acquire both cerebral perfusion and cerebrovascular reactivity maps in one imaging sequence.
基于脱氧的动态对比增强磁共振成像（dDSC）先前已利用呼吸刺激来调节血氧含量，作为灌注加权磁共振成像中注射钆剂之外的内源性对比剂来源。这项研究提出使用呼气末二氧化碳分压（ ）的正弦调制，该方法先前已用于测量脑血管反应性，以诱导对比增强梯度回波信号损失来测量脑灌注。对10名健康志愿者（年龄37±11岁，60%为女性）进行了实验，并在频域中应用示踪动力学模型来计算脑血流量、脑血容量、平均通过时间和时间延迟。将这些灌注估计值与参考技术进行比较，包括基于钆剂的DSC、动脉自旋标记和相位对比。我们的结果显示了 与临床对照方法之间的区域一致性。 能够结合基线灌注估计生成可靠的脑血管反应性图谱。总体而言，这项研究证明了使用正弦二氧化碳呼吸模式在一个成像序列中同时获取脑灌注和脑血管反应性图谱的可行性。
