Reed Megan K, Imperato Nicholas S, Bowles Jeanette M, Salcedo Venise J, Guth Amanda, Rising Kristin L
Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, 1015 Walnut Street, Curtis Building, Suite 704, Philadelphia, PS 19107, United States.
Center for Connected Care, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PS, United States.
Drug Alcohol Depend Rep. 2022 Jun 30;4:100074. doi: 10.1016/j.dadr.2022.100074. eCollection 2022 Sep.
Xylazine is an animal tranquilizer increasingly detected in those who have died of an opioid overdose in Philadelphia, PA and elsewhere. Despite an increasing presence of xylazine in the local fentanyl/heroin drug market and its association with ulcers, there are few perspectives about xylazine from people who use drugs and no data about the utility of a hypothetical xylazine test strip.
Between January to May 2021 in Philadelphia, PA, people who used fentanyl/heroin and had previously used fentanyl test strips were queried about xylazine and hypothetical xylazine test strips. Interviews were transcribed and analysis was conducted via conventional content analysis.
Participants (7 spontaneously, 6 after probing, = 13) discussed "tranq" (i.e., xylazine) in the fentanyl/heroin supply. None enjoyed tranq or wanted it in their fentanyl/heroin. Participants suspected xylazine saturation of the fentanyl/heroin market, disliked the sensation of the drug, and had safety concerns about xylazine exposure. Participants did not indicate concerns about overdose. All were interested in hypothetical xylazine test strips. While previous literature indicates that some people enjoy tranq in their fentanyl/heroin, our findings differed, with participants expressing concern about the consequences of undesired exposure. The interest expressed for xylazine test strips by people who use fentanyl/heroin is an important opportunity to center their voices in the development of innovations designed to mitigate the harms of unwanted adulterant exposure.
In the present study, people who use fentanyl/heroin indicated an interest to test their drug for the presence of xylazine prior to use.
赛拉嗪是一种动物镇静剂，在宾夕法尼亚州费城及其他地区死于阿片类药物过量的人群中越来越多地被检测到。尽管赛拉嗪在当地芬太尼/海洛因毒品市场中的存在日益增加，且与溃疡有关，但吸毒者对赛拉嗪的看法很少，也没有关于假想的赛拉嗪检测试纸效用的数据。
2021年1月至5月期间，在宾夕法尼亚州费城，对使用过芬太尼/海洛因且之前使用过芬太尼检测试纸的人询问了有关赛拉嗪和假想的赛拉嗪检测试纸的情况。访谈内容被转录，并通过常规内容分析法进行分析。
参与者（7人自发提及，6人经询问后提及，共13人）讨论了芬太尼/海洛因供应中的“镇静剂”（即赛拉嗪）。没有人喜欢镇静剂，也不想在他们的芬太尼/海洛因中含有它。参与者怀疑芬太尼/海洛因市场中赛拉嗪饱和，不喜欢这种药物的感觉，并对接触赛拉嗪存在安全担忧。参与者没有表示对过量用药的担忧。所有人都对假想的赛拉嗪检测试纸感兴趣。虽然之前的文献表明，一些人喜欢在他们的芬太尼/海洛因中含有镇静剂，但我们的研究结果不同，参与者对意外接触的后果表示担忧。使用芬太尼/海洛因的人对赛拉嗪检测试纸表达的兴趣是一个重要机会，可让他们的声音在旨在减轻意外接触掺假物危害的创新研发中得到重视。
在本研究中，使用芬太尼/海洛因的人表示有兴趣在使用前检测其毒品中是否含有赛拉嗪。
