Song Jingfang, He Jian, Yang Lin, Wang Weiguo, Bai Qinqin, Feng Wei, Li Ranhui
The Second Affiliated Hospital, Department of Pediatrics, Institute of Pathogenic Biology, Hengyang Medical School, University of South China and Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang, Hunan 421001, China.
Institute of Pharmacy and Pharmacology, Hengyang Medical School, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China.
Bioinorg Chem Appl. 2023 Feb 15;2023:1689455. doi: 10.1155/2023/1689455. eCollection 2023.
To inhibit the growth of bacteria, the DA-PPI nanozyme with enhanced peroxidase-like activity was synthesized. The DA-PPI nanozyme was obtained by depositing high-affinity element iridium (Ir) on the surface of Pd-Pt dendritic structures. The morphology and composition of DA-PPI nanozyme were characterized using SEM, TEM, and XPS. The kinetic results showed that the DA-PPI nanozyme possessed a higher peroxidase-like activity than that of Pd-Pt dendritic structures. The PL, ESR, and DFT were employed to explain the high peroxidase activity. As a proof of concept, the DA-PPI nanozyme could effectively inhibit (G) and (G) due to its high peroxidase-like activity. The study provides a new idea for the design of high active nanozymes and their application in the field of antibacterial.
为抑制细菌生长，合成了具有增强类过氧化物酶活性的DA-PPI纳米酶。通过在Pd-Pt树枝状结构表面沉积高亲和力元素铱（Ir）获得DA-PPI纳米酶。利用扫描电子显微镜（SEM）、透射电子显微镜（TEM）和X射线光电子能谱（XPS）对DA-PPI纳米酶的形态和组成进行了表征。动力学结果表明，DA-PPI纳米酶具有比Pd-Pt树枝状结构更高的类过氧化物酶活性。采用光致发光（PL）、电子顺磁共振（ESR）和密度泛函理论（DFT）来解释其高过氧化物酶活性。作为概念验证，由于其高类过氧化物酶活性，DA-PPI纳米酶可有效抑制（G）和（G）。该研究为高活性纳米酶的设计及其在抗菌领域的应用提供了新思路。
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