Zeng Fa, Zhang Luodan, Deng Fang, Lou Shuiping
Shenzhen Longhua Maternity and Child Healthcare Hospital, Shenzhen, China.
Department of Nephrology, Anhui Provincial Children's Hospital, Children's Hospital of Anhui Medical University, Hefei, China.
Front Cell Dev Biol. 2023 Feb 10;11:1115229. doi: 10.3389/fcell.2023.1115229. eCollection 2023.
Di (2-ethyl-hexyl) phthalate (DEHP), one of endocrine-disrupting chemicals (EDCs), has widespread concern due to its serious health hazards. Exposure to DEHP in the early stage of life affects fetal metabolic and endocrine function, which even would cause genetic lesions. To date, it is widely believed that the increasing incidence of childhood obesity and diabetes in adolescents is related to the impact of DEHP on glucose and lipid homeostasis in children. However, there remains a knowledge gap to recognize these adverse effects. Thus, in this review, besides the exposure routes and levels of DEHP, we further outline the effects of early-life exposure to DEHP on children and potential mechanisms, focusing on the aspect of metabolic and endocrine homeostasis.
邻苯二甲酸二（2-乙基己基）酯（DEHP）是一种内分泌干扰化学物质（EDC），因其严重的健康危害而受到广泛关注。生命早期接触DEHP会影响胎儿的代谢和内分泌功能，甚至会导致基因损伤。迄今为止，人们普遍认为青少年儿童肥胖和糖尿病发病率的上升与DEHP对儿童葡萄糖和脂质稳态的影响有关。然而，在认识这些不良反应方面仍存在知识空白。因此，在本综述中，除了DEHP的暴露途径和水平外，我们还进一步概述了生命早期接触DEHP对儿童的影响及其潜在机制，重点关注代谢和内分泌稳态方面。
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