胎儿邻苯二甲酸酯和双酚类物质与儿童脂质和葡萄糖代谢。基于人群的前瞻性队列研究。
Fetal phthalates and bisphenols and childhood lipid and glucose metabolism. A population-based prospective cohort study.
机构信息
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Paediatrics, Erasmus MC - Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, NY 12201, USA; Department of Chemistry, The Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.
出版信息
Environ Int. 2020 Nov;144:106063. doi: 10.1016/j.envint.2020.106063. Epub 2020 Sep 1.
BACKGROUND AND AIMS
Fetal exposure to endocrine disruptors such as phthalates and bisphenols may lead to developmental metabolic adaptations. We examined associations of maternal phthalate and bisphenol urine concentrations during pregnancy with lipids, insulin, and glucose concentrations at school age.
METHODS
In a population-based, prospective cohort study among 757 mother-child pairs, we measured maternal phthalate and bisphenol urine concentrations in first, second and third trimester of pregnancy. We measured non-fasting lipids, glucose and insulin blood concentrations of their children at a mean age of 9.7 (standard deviation 0.2) years. Analyses were performed for boys and girls separately.
RESULTS
An interquartile range (IQR) higher natural log transformed third trimester maternal urine phthalic acid concentration was associated with a 0.20 (95% confidence interval (CI) 0.07-0.34) standard deviation score (SDS) higher triglycerides concentration among boys. Maternal bisphenol urine concentrations were not associated with non-fasting lipid concentrations during childhood. An IQR higher natural log transformed second trimester maternal high molecular weight phthalates (HMWP) and di-2-ethylhexylphthalate (DEHP) urine concentration were associated with a 0.19 (95% CI 0.31-0.07) respectively 0.18 (95% CI 0.31-0.06) SDS lower glucose concentration among boys. An IQR higher natural log transformed third trimester maternal bisphenol F urine concentration was associated with a 0.22 (95% CI 0.35-0.09) SDS lower non-fasting insulin concentration among boys.
CONCLUSIONS
Our results suggest potential persisting sex specific effects of fetal exposure to phthalates and bisphenols on childhood lipid concentrations and glucose metabolism. Future studies are needed for replication and exploring underlying mechanisms.
背景与目的
胎儿暴露于邻苯二甲酸酯和双酚等内分泌干扰物可能导致发育代谢适应。我们研究了妊娠期间母体邻苯二甲酸酯和双酚尿液浓度与儿童期血脂、胰岛素和血糖浓度的相关性。
方法
在一项基于人群的前瞻性队列研究中，我们测量了 757 对母婴尿液中的邻苯二甲酸酯和双酚浓度，包括妊娠第一、二、三期。我们在儿童平均年龄为 9.7 岁（标准差为 0.2）时测量了其非禁食血脂、血糖和胰岛素血浓度。对男孩和女孩分别进行了分析。
结果
第三期母体尿液邻苯二甲酸浓度的四分位距（IQR）每增加一个自然对数，男孩的甘油三酯浓度就会升高 0.20（95%置信区间（CI）0.07-0.34）标准差评分（SDS）。母体双酚尿液浓度与儿童期非禁食血脂浓度无关。第二期母体高分子量邻苯二甲酸酯（HMWP）和邻苯二甲酸二（2-乙基己基）酯（DEHP）尿液浓度的 IQR 每增加一个自然对数，男孩的血糖浓度就会分别降低 0.19（95%CI 0.31-0.07）和 0.18（95%CI 0.31-0.06）SDS。第三期母体尿液双酚 F 浓度的 IQR 每增加一个自然对数，男孩的非禁食胰岛素浓度就会降低 0.22（95%CI 0.35-0.09）SDS。
结论
我们的研究结果表明，胎儿暴露于邻苯二甲酸酯和双酚对儿童期血脂浓度和葡萄糖代谢存在潜在持续的性别特异性影响。需要进一步的研究来复制和探索潜在的机制。
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