Hacettepe University Faculty of Medicine, Department of Ophthalmology, Ankara, Türkiye.
Ulucanlar Eye Training and Research Hospital, Ankara, Türkiye.
Turk J Ophthalmol. 2023 Feb 24;53(1):18-22. doi: 10.4274/tjo.galenos.2022.26460.
Duane syndrome (DS) is typically characterized by abduction and/or adduction deficiency accompanied by eyelid and ocular motility disturbances. Maldevelopment or absence of the sixth nerve has been shown to be the causative factor. The aim of the present study was to investigate static and dynamic pupillary characteristics in patients with DS and compare the results with those of healthy eyes.
Patients with unilateral isolated DS and no history of ocular surgery were enrolled in the study. Healthy subjects with a best corrected visual acuity (BCVA) of 1.0 or higher were assigned to the control group. All subjects underwent complete ophthalmological examination and pupillometry measurements (MonPack One, Vision Monitor System, Metrovision, Perenchies, France) including static and dynamic pupil evaluation.
A total of 74 patients (22 with DS and 52 healthy subjects) were included in the study. The mean age of the DS patients and healthy subjects was 11.05±5.19 and 12.54±4.05 years, respectively (p=0.188). There was no difference in sex distribution (p=0.502). Mean BCVA differed significantly between eyes with DS and healthy eyes, and between healthy eyes and the fellow eyes of DS patients (p<0.05). No significant difference was found in any static or dynamic pupillometry parameters (p>0.05 for all).
In the light of the results of the present study, the pupil seems to be not involved in DS. Larger studies including more patients with different types of DS in different age groups or comprising patients with non-isolated DS may reveal different findings.
Duane 综合征（DS）的典型特征为外展和/或内收功能不足，并伴有眼睑和眼球运动障碍。现已证实第六神经发育不良或缺失是其致病因素。本研究旨在探讨 DS 患者的静态和动态瞳孔特征，并与健康眼进行比较。
本研究纳入了单侧孤立性 DS 且无眼部手术史的患者。选择最佳矫正视力（BCVA）为 1.0 或更高的健康受试者作为对照组。所有受试者均接受了全面的眼科检查和瞳孔测量（MonPack One，Vision Monitor System，Metrovision，Perenchies，法国），包括静态和动态瞳孔评估。
共纳入 74 例患者（22 例 DS 患者和 52 例健康受试者）。DS 患者和健康受试者的平均年龄分别为 11.05±5.19 岁和 12.54±4.05 岁（p=0.188）。两组性别分布无差异（p=0.502）。DS 眼与健康眼之间以及 DS 患者对侧眼与健康眼之间的平均 BCVA 差异有统计学意义（p<0.05）。任何静态或动态瞳孔测量参数均无显著差异（p>0.05）。
根据本研究结果，瞳孔似乎未参与 DS。纳入不同年龄组、不同类型 DS 患者或包括非孤立性 DS 患者的更大规模研究可能会得出不同的发现。
