Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-gu, Pohang, Gyeongbuk 790-784, Korea.
Department of Electrical Engineering, Convergence IT Engineering, and Mechanical Engineering, and Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-gu, Pohang, Gyeongbuk 790-784, Korea.
ACS Appl Mater Interfaces. 2023 Mar 8;15(9):11609-11620. doi: 10.1021/acsami.3c01858. Epub 2023 Feb 27.
Although spherical gold (Au) nanoparticles have remarkable photothermal conversion efficiency and photostability, their weak absorption in the near-infrared (NIR) region and poor penetration into deep tissues have limited further applications to NIR light-mediated photoacoustic (PA) imaging and noninvasive photothermal cancer therapy. Here, we developed bimetallic hyaluronate-modified Au-platinum (HA-Au@Pt) nanoparticles for noninvasive cancer theranostics by NIR light-mediated PA imaging and photothermal therapy (PTT). The growth of Pt nanodots on the surface of spherical Au nanoparticles enhanced the absorbance in the NIR region and broadened the absorption bandwidth of HA-Au@Pt nanoparticles by the surface plasmon resonance (SPR) coupling effect. In addition, HA facilitated the transdermal delivery of HA-Au@Pt nanoparticles through the skin barrier and enabled clear tumor-targeted PA imaging. Compared to conventional PTT injection, HA-Au@Pt nanoparticles were noninvasively delivered into deep tumor tissues and completely ablated the targeted tumor tissues by NIR light irradiation. Taken together, we could confirm the feasibility of HA-Au@Pt nanoparticles as a NIR light-mediated biophotonic agent for noninvasive skin cancer theranostics.
虽然球形金（Au）纳米粒子具有显著的光热转换效率和光稳定性，但它们在近红外（NIR）区域的吸收较弱，并且难以穿透深层组织，这限制了它们在近红外光介导的光声（PA）成像和非侵入性光热癌症治疗中的进一步应用。在这里，我们通过近红外光介导的 PA 成像和光热治疗（PTT）开发了双金属透明质酸修饰的 Au-铂（HA-Au@Pt）纳米粒子，用于非侵入性癌症治疗。Pt 纳米点在球形 Au 纳米粒子表面的生长通过表面等离子体共振（SPR）耦合效应增强了 HA-Au@Pt 纳米粒子在 NIR 区域的吸收，并拓宽了它们的吸收带宽。此外，HA 促进了 HA-Au@Pt 纳米粒子通过皮肤屏障的透皮传递，并能够实现清晰的肿瘤靶向 PA 成像。与传统的 PTT 注射相比，HA-Au@Pt 纳米粒子通过非侵入性方式递送至深层肿瘤组织，并通过近红外光照射完全消融靶向肿瘤组织。总之，我们可以确认 HA-Au@Pt 纳米粒子作为一种近红外光介导的生物光子剂用于非侵入性皮肤癌治疗的可行性。
