Sun Mengmeng, Liu Fei, Zhu Yukun, Wang Wansheng, Hu Jin, Liu Jing, Dai Zhifei, Wang Kun, Wei Yen, Bai Jing, Gao Weiping
Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Nanoscale. 2016 Feb 28;8(8):4452-7. doi: 10.1039/c6nr00056h.
The challenge in photothermal therapy (PTT) is to develop biocompatible photothermal transducers that can absorb and convert near-infrared (NIR) light into heat with high efficiency. Herein, we report salt-induced aggregation of gold nanoparticles (GNPs) in biological media to form highly efficient and biocompatible NIR photothermal transducers for PTT and photothermal/photoacoustic (PT/PA) imaging of cancer. The GNP depots in situ formed by salt-induced aggregation of GNPs show strong NIR absorption induced by plasmonic coupling between adjacent GNPs and very high photothermal conversion efficiency (52%), enabling photothermal destruction of tumor cells. More interestingly, GNPs in situ aggregate in tumors to form GNP depots, enabling simultaneous PT/PA imaging and PTT of the tumors. These findings may provide a simple and effective way to develop a new class of intelligent and biocompatible NIR photothermal transducers with high efficiency for PT/PA imaging and PTT.
光热疗法（PTT）面临的挑战是开发能够高效吸收近红外（NIR）光并将其转化为热的生物相容性光热换能器。在此，我们报道了金纳米颗粒（GNPs）在生物介质中通过盐诱导聚集形成用于癌症PTT和光热/光声（PT/PA）成像的高效且生物相容的NIR光热换能器。由GNPs盐诱导聚集原位形成的GNP库显示出由相邻GNPs之间的等离子体耦合诱导的强NIR吸收以及非常高的光热转换效率（52%），能够对肿瘤细胞进行光热破坏。更有趣的是，GNPs在肿瘤中原位聚集形成GNP库，能够实现肿瘤的同时PT/PA成像和PTT。这些发现可能为开发一类新型高效的用于PT/PA成像和PTT的智能且生物相容的NIR光热换能器提供一种简单有效的方法。
