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CFTR-a (novel) target in ARDS : Commentary on "Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation", Erfinanda et al., Sci. Transl. Med. 14, eabg8577 (2022).

作者信息

Frick Manfred

机构信息

Institute of General Physiology, Ulm University, Ulm, Germany.

出版信息

Pflugers Arch. 2023 Apr;475(4):417-419. doi: 10.1007/s00424-023-02800-4. Epub 2023 Feb 27.

DOI:10.1007/s00424-023-02800-4
PMID:36847846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9969384/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae6/10011284/f12899e0a442/424_2023_2800_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae6/10011284/f12899e0a442/424_2023_2800_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae6/10011284/f12899e0a442/424_2023_2800_Fig1_HTML.jpg

相似文献

1
CFTR-a (novel) target in ARDS : Commentary on "Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation", Erfinanda et al., Sci. Transl. Med. 14, eabg8577 (2022).急性呼吸窘迫综合征中的CFTR-a（新型）靶点：对《内皮细胞CFTR缺失导致肺部感染中屏障功能衰竭和水肿形成，CFTR增强剂可作为靶点》的评论，埃尔菲南达等人，《科学·转化医学》14卷，eabg8577（2022年）
Pflugers Arch. 2023 Apr;475(4):417-419. doi: 10.1007/s00424-023-02800-4. Epub 2023 Feb 27.
2
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Sci Transl Med. 2022 Dec 7;14(674):eabg8577. doi: 10.1126/scitranslmed.abg8577.
3
Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation.血小板中囊性纤维化跨膜电导调节因子功能障碍导致肺部过度炎症。
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本文引用的文献

1
Cystic Fibrosis: Emergence of Highly Effective Targeted Therapeutics and Potential Clinical Implications.囊性纤维化：高效靶向治疗药物的出现及其潜在的临床意义。
Am J Respir Crit Care Med. 2020 May 15;201(10):1193-1208. doi: 10.1164/rccm.201910-1943SO.
2
Pathogenesis of Acute Respiratory Distress Syndrome.急性呼吸窘迫综合征的发病机制。
Semin Respir Crit Care Med. 2019 Feb;40(1):31-39. doi: 10.1055/s-0039-1683996. Epub 2019 May 6.
3
Influenza virus infection alters ion channel function of airway and alveolar cells: mechanisms and physiological sequelae.
流感病毒感染改变气道和肺泡细胞的离子通道功能：机制与生理后果。
Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L845-L858. doi: 10.1152/ajplung.00244.2017. Epub 2017 Aug 3.
4
Genotypes and phenotypes in cystic fibrosis and cystic fibrosis transmembrane regulator-related disorders.囊性纤维化及囊性纤维化跨膜传导调节因子相关疾病中的基因型与表型
Semin Respir Crit Care Med. 2015 Apr;36(2):180-93. doi: 10.1055/s-0035-1547318. Epub 2015 Mar 31.
5
TRPV4: an exciting new target to promote alveolocapillary barrier function.瞬时受体电位香草酸亚型4（TRPV4）：促进肺泡毛细血管屏障功能的一个令人兴奋的新靶点。
Am J Physiol Lung Cell Mol Physiol. 2014 Dec 1;307(11):L817-21. doi: 10.1152/ajplung.00254.2014. Epub 2014 Oct 3.
6
Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene.定义囊性纤维化跨膜电导调节因子基因变异的疾病责任。
Nat Genet. 2013 Oct;45(10):1160-7. doi: 10.1038/ng.2745. Epub 2013 Aug 25.
7
The acute respiratory distress syndrome: pathogenesis and treatment.急性呼吸窘迫综合征：发病机制与治疗。
Annu Rev Pathol. 2011;6:147-63. doi: 10.1146/annurev-pathol-011110-130158.
8
Effect of deleting the R domain on CFTR-generated chloride channels.删除R结构域对CFTR生成的氯离子通道的影响。
Science. 1991 Jul 12;253(5016):205-7. doi: 10.1126/science.1712985.
9
Demonstration that CFTR is a chloride channel by alteration of its anion selectivity.通过改变其阴离子选择性来证明囊性纤维化跨膜传导调节因子是一种氯离子通道。
Science. 1991 Jul 12;253(5016):202-5. doi: 10.1126/science.1712984.