Liao Xingyue, Wu Liujianxiong, Yin Dan, Tian Dewei, Zhou Cuilan, Liu Jun, Li Suyun, Zhou Jing, Nie Yulin, Liao Hongqing, Peng Cuiying
Department of Cell Biology and Genetics, Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of Ecological Environment and Critical Human Dise Ases Prevention of Hunan Province, Department of Education, Key Laboratory of Hengyang City On Biological Toxicology and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and Health Hazards, University of South China, Hengyang, 421001, Hunan, China.
Department of Obstetrics and Gynecology, the Second Affiliated Hospital, University of South China, 30# Jiefang Road, Hengyang, 421001, Hunan, PR China.
Mol Biol Rep. 2023 May;50(5):4527-4534. doi: 10.1007/s11033-023-08331-6. Epub 2023 Feb 27.
Follicles consist of specialized somatic cells that encase a single oocyte. Follicle development is a process regulated by a variety of endocrine, paracrine, and secretory factors that work together to select follicles for ovulation. Zinc is an essential nutrient for the human body and is involved in many physiological processes, such as follicle development, immune response, homeostasis, oxidative stress, cell cycle progression, DNA replication, DNA damage repair, apoptosis, and aging. Zinc deficiency can lead to blocked oocyte meiotic process, cumulus expansion, and follicle ovulation. In this mini-review, we summarize the the role of zinc in follicular development.
卵泡由包裹单个卵母细胞的特化体细胞组成。卵泡发育是一个由多种内分泌、旁分泌和分泌因子调节的过程，这些因子共同作用以选择卵泡进行排卵。锌是人体必需的营养素，参与许多生理过程，如卵泡发育、免疫反应、内环境稳定、氧化应激、细胞周期进程、DNA复制、DNA损伤修复、细胞凋亡和衰老。锌缺乏可导致卵母细胞减数分裂过程受阻、卵丘扩展和卵泡排卵。在本综述中，我们总结了锌在卵泡发育中的作用。
