Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
J Clin Endocrinol Metab. 2023 Aug 18;108(9):2353-2362. doi: 10.1210/clinem/dgad110.
There is little evidence regarding the joint effect of serum adipocyte fatty acid binding protein (A-FABP) levels and obesity phenotype on the risk of cardiovascular events.
To explore the association between serum A-FABP levels and obesity phenotype defined by fat percentage (fat%) and visceral fat area (VFA), and their joint impact on incident cardiovascular events.
A total of 1345 residents (579 men and 766 women) without previous cardiovascular diseases at baseline, with body composition and serum A-FABP data available, were included. A bioelectrical impedance analyzer and magnetic resonance imaging were used to assess fat% and VFA, respectively.
During a mean follow-up of 7.6 years, 136 cases of cardiovascular events (13.9 per 1000 person-years) occurred. Per 1-unit increase in loge-transformed A-FABP levels was associated with an increase in cardiovascular events risk (hazard ratio [HR] 1.87, 95% CI 1.33-2.63). The highest tertiles of fat% and VFA levels were related to higher risks of cardiovascular events (fat%: HR 2.38, 95% CI 1.49-3.81; VFA: HR 1.79, 95% CI 1.09-2.93). The association between A-FABP levels and cardiovascular events was more pronounced in participants with low fat%, regardless of VFA levels. The joint effect of high A-FABP levels and obesity resulted in a greater risk of cardiovascular events.
Serum A-FABP levels were significantly associated with the risk of cardiovascular events, and this pattern of association was more prominent among the population with low fat%, which was independent of VFA.
关于血清脂肪细胞脂肪酸结合蛋白（A-FABP）水平和肥胖表型对心血管事件风险的综合影响，相关证据有限。
探讨血清 A-FABP 水平与脂肪百分比（fat%）和内脏脂肪面积（VFA）定义的肥胖表型之间的相关性，以及它们对心血管事件发生的联合影响。
共纳入 1345 名基线时无既往心血管疾病且具有身体成分和血清 A-FABP 数据的居民（579 名男性和 766 名女性）。使用生物电阻抗分析仪和磁共振成像分别评估 fat%和 VFA。
在平均 7.6 年的随访期间，发生了 136 例心血管事件（每 1000 人年 13.9 例）。loge 转换后 A-FABP 水平每增加 1 个单位，心血管事件风险增加（风险比 [HR] 1.87，95%置信区间 [CI] 1.33-2.63）。最高三分位的 fat%和 VFA 水平与心血管事件风险升高相关（fat%：HR 2.38，95%CI 1.49-3.81；VFA：HR 1.79，95%CI 1.09-2.93）。无论 VFA 水平如何，A-FABP 水平与心血管事件之间的关联在 fat%较低的参与者中更为明显。A-FABP 水平升高和肥胖的联合作用导致心血管事件的风险增加。
血清 A-FABP 水平与心血管事件风险显著相关，这种关联模式在 fat%较低的人群中更为明显，且独立于 VFA。
