Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Haeundaen-gu, Busan, Republic of Korea.
Diabetes Res Clin Pract. 2013 Aug;101(2):210-7. doi: 10.1016/j.diabres.2013.05.014. Epub 2013 Jul 4.
Adipocyte fatty acid-binding protein (A-FABP) plays a key role in obesity-related insulin resistance and inflammation which may be involved in the pathogenesis of sarcopenic obesity (SO). This study examined the association of SO with serum A-FABP levels in Korean adults.
Two hundred ninety eight adults aged 20-70 years were examined using dual X-ray absorptiometry and computed tomography and measuring serum A-FABP levels. Sarcopenia was defined as the appendicular skeletal muscle mass (ASM) divided by weight (%) of <1 SD below the mean values of young adults in both sexes. Obesity was defined as visceral fat area (VFA) ≥ 100 cm(2).
Serum A-FABP levels were higher in groups with SO compared to non-SO groups in both men and women. In the unadjusted model, serum A-FABP levels were positively associated with VFA and negatively associated with ASM/weight. Even after adjusting for possible confounding factors, ASM/weight was found to be independently and negatively associated with serum A-FABP levels. In addition, multiple logistic regression analysis showed that increased serum levels of A-FABP were independently associated with the presence of SO.
The present findings indicate that serum A-FABP levels may be valuable markers of the presence of SO.
脂肪细胞脂肪酸结合蛋白（A-FABP）在肥胖相关的胰岛素抵抗和炎症中发挥关键作用，而这些可能与肌肉减少性肥胖（SO）的发病机制有关。本研究旨在探讨韩国成年人中 SO 与血清 A-FABP 水平的相关性。
采用双能 X 线吸收法和计算机断层扫描对 298 名年龄在 20-70 岁的成年人进行检查，并测量血清 A-FABP 水平。肌少症定义为四肢骨骼肌质量（ASM）除以体重（%），低于男性和女性年轻成年人平均值的 1 个标准差。肥胖定义为内脏脂肪面积（VFA）≥100cm²。
在男性和女性中，SO 组的血清 A-FABP 水平均高于非 SO 组。在未调整模型中，血清 A-FABP 水平与 VFA 呈正相关，与 ASM/体重呈负相关。即使在调整了可能的混杂因素后，ASM/体重仍与血清 A-FABP 水平呈独立负相关。此外，多因素逻辑回归分析表明，血清 A-FABP 水平升高与 SO 的存在独立相关。
本研究结果表明，血清 A-FABP 水平可能是 SO 存在的有价值标志物。
