Chiang Simon, Lee Stella E
Department of Surgery, 1861Brigham and Women's Hospital, Division of Otolaryngology-Head & Neck Surgery, Harvard Medical School, Boston, Massachusetts.
Am J Rhinol Allergy. 2023 Mar;37(2):193-197. doi: 10.1177/19458924231154061.
Epithelial barrier disturbances in CRSwNP patients play an important role in both the innate and adaptive immune responses, contributing to chronic inflammation, olfactory dysfunction, and impairments in quality of life.
To evaluate the role of the sinonasal epithelium in disease and health, review the pathophysiology of epithelial barrier dysfunction in CRSwNP, and the immunologic targets for treatment.
Literature review.
Blockade of cytokines such as thymic stromal lymphopoietin (TSLP), IL-4, and IL-13 have shown promise in barrier restoration and IL-13, specifically may be central to olfactory dysfunction.
The sinonasal epithelium plays a crucial role in the health and function of the mucosa and immune response. Increased understanding of the local immunologic dysfunction has led to several therapeutics that can potentially restore epithelial barrier function and olfaction. Real world and comparative effectiveness studies are needed.
慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）患者的上皮屏障紊乱在先天免疫和适应性免疫反应中均起重要作用，导致慢性炎症、嗅觉功能障碍及生活质量受损。
评估鼻窦上皮在疾病与健康中的作用，综述CRSwNP上皮屏障功能障碍的病理生理学及治疗的免疫靶点。
文献综述。
阻断细胞因子如胸腺基质淋巴细胞生成素（TSLP）、白细胞介素-4（IL-4）和白细胞介素-13（IL-13）在屏障恢复方面已显示出前景，尤其是IL-13可能是嗅觉功能障碍的关键因素。
鼻窦上皮在黏膜健康与功能及免疫反应中起关键作用。对局部免疫功能障碍的深入了解已催生了几种可能恢复上皮屏障功能和嗅觉的治疗方法。尚需开展真实世界研究和比较有效性研究。
