前列腺素E1对体内自体标记血小板在人动脉粥样硬化病变上沉积的影响。
Effect of prostaglandin E1 on deposition of autologous labelled platelets onto human atherosclerotic lesions in vivo.
作者信息
Sinzinger H, O'Grady J, Fitscha P
机构信息
Department of Nuclear Medicine, University of Vienna, Austria.
出版信息
Postgrad Med J. 1987 Apr;63(738):245-7. doi: 10.1136/pgmj.63.738.245.
Abstract
The effects of infusions of prostaglandin E1 (PGE1) on platelet deposition at atherosclerotic sites in vivo in man have been examined. Thirteen patients with atherosclerotic vascular disease received intravenous PGE1 25 mg/kg/min for 6 hours daily for 5 days. Prostaglandin E1 had no effect on platelet uptake at atherosclerotic sites but prolonged platelet half-life significantly (P less than 0.001).
摘要
已对前列腺素E1（PGE1）输注对人体体内动脉粥样硬化部位血小板沉积的影响进行了研究。13例动脉粥样硬化性血管疾病患者每天静脉输注PGE1，剂量为25毫克/千克/分钟，持续6小时，共5天。前列腺素E1对动脉粥样硬化部位的血小板摄取没有影响，但显著延长了血小板半衰期（P<0.001）。
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