Sinzinger H, Reiter S
Prostaglandins Leukot Med. 1984 Mar;13(3):281-8. doi: 10.1016/0262-1746(84)90041-6.
During continuous long-term prostacyclin infusion an intra- and post-infusion rebound of platelets has been reported. During the present study 8 patients suffering from peripheral vascular disease in stage IIb according to Fontaine have been infused intravenously at a constant rate of 5 ng/kg/minute for seven days. Throughout this time the platelet function parameters were followed daily in the morning. An intrainfusion platelet rebound occurs using PGE1 as well. In comparison to the data for PGI2 published earlier it is noteworthy that the rebound for PGE1 occurs faster and more intensive. We conclude that for both the antiaggregatory prostaglandins PGE1 and PGI2, an intermittent treatment scheme seems to be optimal at the moment.
据报道，在持续长期输注前列环素期间，会出现输注中和输注后的血小板反弹。在本研究中，8例根据Fontaine分级处于IIb期的外周血管疾病患者，以5 ng/kg/分钟的恒定速率静脉输注7天。在此期间，每天早晨跟踪血小板功能参数。使用PGE1时也会出现输注期间的血小板反弹。与之前发表的PGI2数据相比，值得注意的是，PGE1的反弹发生得更快且更强烈。我们得出结论，对于抗聚集前列腺素PGE1和PGI2，目前间歇性治疗方案似乎是最佳的。
