Department of Philosophy, Binghamton University, Binghamton, New York.
Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Binghamton University, Binghamton, New York.
Am J Trop Med Hyg. 2023 Feb 27;108(4):801-806. doi: 10.4269/ajtmh.21-0583. Print 2023 Apr 5.
Neglected tropical diseases (NTDs) receive relatively little research and development but have a tremendous impact on lifespan and livelihood. Here, we use existing data on the need for drugs, their efficacy, and their treatment percentages to estimate the impacts of various regimens on the global burden of several NTDs: schistosomiasis, onchocerciasis, lymphatic filariasis, and three soil-transmitted helminths (STHs) over time. For an interactive visualization of our models' results, see https://www.global-health-impact.org/. In 2015, our NTD models estimate that treatment averted 2,778,131.78 disability-adjusted life years (DALYs). Together, treatments targeting STHs together averted 51.05% of the DALYs averted from all NTD treatments, whereas schistosomiasis, lymphatic filariasis, and onchocerciasis medicines averted 40.21%, 7.56%, and 1.18%, respectively. Our models highlight the importance of focusing not just on the burden of these diseases but also on their alleviation in the effort to expand access to treatment.
被忽视的热带病（NTDs）得到的研究和开发相对较少，但对寿命和生计有巨大影响。在这里，我们利用现有关于药物需求、疗效和治疗百分比的数据，来估计各种方案对几种 NTDs（血吸虫病、盘尾丝虫病、淋巴丝虫病和三种土壤传播性蠕虫）全球负担的影响：随着时间的推移。要查看我们模型结果的交互式可视化，请访问 https://www.global-health-impact.org/。2015 年，我们的 NTD 模型估计治疗可预防 2,778,131.78 个残疾调整生命年（DALYs）。针对 STH 的治疗一起预防了所有 NTD 治疗中预防的 DALYs 的 51.05%，而血吸虫病、淋巴丝虫病和盘尾丝虫病药物预防了 40.21%、7.56%和 1.18%。我们的模型强调，不仅要关注这些疾病的负担，还要关注它们的缓解，以努力扩大治疗机会。
