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评估影响载紫杉醇抗癌药物涂层金纳米粒子用于乳腺癌治疗的参数。

Evaluation of the parameters affecting the loading of anticancer drug Paclitaxel on coated gold nanoparticles for breast cancer treatment.

机构信息

Department of Biomedical Engineering, Applied Biophotonics Research Center, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran.

Department of Medical Nanotechnology, Applied Biophotonics Research Center, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran.

出版信息

IET Nanobiotechnol. 2023 May;17(3):234-245. doi: 10.1049/nbt2.12121. Epub 2023 Feb 27.

DOI:10.1049/nbt2.12121
PMID:36849875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10190534/
Abstract

The purpose of this study is the design and synthesis of gold nanoparticles (GNPs) conjugated with paclitaxel and to investigate the parameters affecting the stability of synthesised nanoparticles with drug delivery capability. Here, synthesised GNPs were coated with polyethylene glycol. Then these particles were conjugated with paclitaxel under different conditions and the physical and structural characteristics, as well as the factors affecting the loading of paclitaxel on nanoparticles, were evaluated by ultraviolet spectrophotometer, fourier transform infrared spectroscopy, transmission electron microscopy, dynamic light scattering and zeta potential apparatus. It was found that pegylated GNPs have a limited loading capacity at the time of 24 h of incubation and the Paclitaxel loading was observed to be pH dependent. The use of these particles in the treatment of breast cancer (MCF7) was also investigated using the MTT test. It was determined that the survival percentage of MCF7 cells in the presence of paclitaxel-bound nanoparticles decreases to about 55% at the maximum measured concentration (690 μM).

摘要

本研究旨在设计和合成金纳米粒子（GNPs）与紫杉醇缀合，并研究影响具有药物递送能力的合成纳米粒子稳定性的参数。在这里，合成的 GNPs 用聚乙二醇（PEG）包被。然后，在不同条件下将这些颗粒与紫杉醇缀合，并通过紫外分光光度计、傅里叶变换红外光谱、透射电子显微镜、动态光散射和zeta 电位仪评估物理和结构特性以及影响紫杉醇在纳米颗粒上负载的因素。结果发现，在孵育 24 小时时，聚乙二醇化 GNPs 的载药量有限，且紫杉醇的载药量与 pH 值有关。还使用 MTT 试验研究了这些颗粒在乳腺癌（MCF7）治疗中的应用。结果表明，在最大测量浓度（690 μM）下，紫杉醇结合纳米颗粒存在时 MCF7 细胞的存活率降低到约 55%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/27a8bd312a86/NBT2-17-234-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/a30b5fa49d95/NBT2-17-234-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/3356b2cf48dc/NBT2-17-234-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/5942fa75a7e1/NBT2-17-234-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/8fab907160e8/NBT2-17-234-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/8cbd4b71e3c1/NBT2-17-234-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/cb75e0bda4c5/NBT2-17-234-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/17f5bd1a63b7/NBT2-17-234-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/ad97e3af63dc/NBT2-17-234-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/f334efc999f7/NBT2-17-234-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/27a8bd312a86/NBT2-17-234-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/a30b5fa49d95/NBT2-17-234-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/3356b2cf48dc/NBT2-17-234-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/5942fa75a7e1/NBT2-17-234-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/8fab907160e8/NBT2-17-234-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/8cbd4b71e3c1/NBT2-17-234-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/cb75e0bda4c5/NBT2-17-234-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/17f5bd1a63b7/NBT2-17-234-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/ad97e3af63dc/NBT2-17-234-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/f334efc999f7/NBT2-17-234-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f52a/10190534/27a8bd312a86/NBT2-17-234-g001.jpg

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本文引用的文献

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Anticancer Agents Med Chem. 2021

[2]
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[3]
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[4]
Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery.

Molecules. 2020-3-5

[5]
The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation.

Polymers (Basel). 2020-2-2

[6]
Folic acid receptor-targeted solid lipid nanoparticles to enhance cytotoxicity of letrozole through induction of caspase-3 dependent-apoptosis for breast cancer treatment.

Pharm Dev Technol. 2020-1-2

[7]
New Folate-Modified Human Serum Albumin Conjugated to Cationic Lipid Carriers for Dual Targeting of Mitoxantrone against Breast Cancer.

Curr Pharm Biotechnol. 2020

[8]
Development and characterization of folic acid-functionalized apoferritin as a delivery vehicle for epirubicin against MCF-7 breast cancer cells.

Artif Cells Nanomed Biotechnol. 2018-11-19

[9]
Cancer prevention from the perspective of global cancer burden patterns.

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[10]
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