Frontier Institute of Science and Technology, State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, P.R. China.
Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Mol Med Rep. 2020 Dec;22(6):4475-4484. doi: 10.3892/mmr.2020.11580. Epub 2020 Oct 11.
Paclitaxel is a potent antineoplastic agent, but poor solubility and resistance have limited its use. Gold nanoparticles (AuNPs) are widely studied as drug carriers because they can be engineered to prevent drug insolubility, carry nucleic acid payloads for gene therapy, target specific tumor cell lines, modulate drug release and amplify photothermal therapy. Consequently, the conjugation of paclitaxel with AuNPs to improve antiproliferative and pro‑apoptotic potency may enable improved clinical outcomes. There are currently a number of different AuNPs under development, including simple drug or nucleic acid carriers and targeted AuNPs that are designed to deliver therapeutic payloads to specific cells. The current study reviewed previous research on AuNPs and the development of AuNP‑based paclitaxel delivery.
紫杉醇是一种有效的抗肿瘤药物，但溶解性差和耐药性限制了其应用。金纳米粒子（AuNPs）作为药物载体得到了广泛的研究，因为它们可以被设计用来防止药物不溶，携带核酸有效载荷进行基因治疗，靶向特定的肿瘤细胞系，调节药物释放和放大光热疗法。因此，将紫杉醇与 AuNPs 结合以提高抗增殖和促凋亡活性，可能会改善临床结果。目前有许多不同的 AuNPs 在开发中，包括简单的药物或核酸载体以及靶向 AuNPs，旨在将治疗有效载荷递送到特定细胞。本研究综述了以前关于 AuNPs 以及基于 AuNP 的紫杉醇递药系统的研究进展。
