Department of Psychology, Shandong Normal University, Jinan, 250358, Shandong, China.
Department of Psychiatry, Shandong Mental Health Center, Shandong University, Jinan, 250014, Shandong, China.
BMC Psychiatry. 2023 Feb 27;23(1):128. doi: 10.1186/s12888-023-04625-y.
Previous studies have shown that depression was associated with HTR3B gene. The aim of this study was to investigate the relationship between polymorphisms of the HTR3B gene and depression and its executive dysfunction in Chinese Han population.
A total of 229 patients with depressive disorder and 202 healthy controls were enrolled. Six Single nucleotide polymorphism sites (SNPs) including rs10789970, rs4938056, rs12421126, rs1176744, rs2276305 and rs12795805 were genotyped by Snapshot. Clinical features were collected using a general demographic questionnaire. The 24-item Hamilton Depression Scale (HAMD) was used to assess the symptoms' severity of the patients. The patients' executive function was assessed using a series of cognitive tests including Maze Test, Symbolic Coding Test, Spatial Span Inverse Order Test, Linking Test, and Emotional Management Test.
The genotypic and allelic distributions of rs1176744 in HTR3B gene were significantly different (χ = 11.129, P = 0.004, χ = 9.288, P = 0.002, respectively) between patients and controls. The A allele was positively correlated with depression. The proportion of A carriers was significantly higher and that of C carriers was lower in patients than those in controls. Patients had significantly lower scores of Spatial Span Inverse Order Test in carriers of A allele at locus rs1176744 and higher scores in carriers of C alleles at locus rs1176744 and rs12795805.
The polymorphisms of HTR3B gene may be associated with depression in Chinese Han population. The A allele of rs1176744 may increase the risk of developing depression and executive dysfunction while C alleles of rs1176744 and rs12795805 may be the protective factors for executive dysfunction in patients with depression.
先前的研究表明，抑郁与 HTR3B 基因有关。本研究旨在探讨中国汉族人群中 HTR3B 基因多态性与抑郁及其执行功能障碍的关系。
共纳入 229 例抑郁症患者和 202 例健康对照者。采用Snapshot 法对 6 个单核苷酸多态性位点（SNPs）rs10789970、rs4938056、rs12421126、rs1176744、rs2276305 和 rs12795805 进行基因分型。采用一般人口学问卷收集临床特征。采用 24 项汉密尔顿抑郁量表（HAMD）评估患者的症状严重程度。采用迷宫测试、符号编码测试、空间广度逆序测试、连线测试和情绪管理测试对患者的执行功能进行评估。
HTR3B 基因 rs1176744 的基因型和等位基因分布在患者和对照组之间差异有统计学意义（χ²=11.129，P=0.004，χ²=9.288，P=0.002）。A 等位基因与抑郁呈正相关。与对照组相比，患者组 rs1176744 的 A 等位基因携带者比例显著较高，而 C 等位基因携带者比例显著较低。在 rs1176744 位点的 A 等位基因携带者中，空间广度逆序测试的得分显著较低，而在 rs1176744 和 rs12795805 位点的 C 等位基因携带者中，得分显著较高。
HTR3B 基因多态性可能与中国汉族人群的抑郁有关。rs1176744 的 A 等位基因可能增加抑郁和执行功能障碍的发病风险，而 rs1176744 和 rs12795805 的 C 等位基因可能是抑郁症患者执行功能障碍的保护因素。
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