Bierbaum Sibylle, Fischer Veronika, Briedigkeit Lutz, Werner Claudius, Hengel Hartmut, Huzly Daniela
Center for Microbiology and Hygiene, Institute for Virology, Medical Center, University of Freiburg, 79104 Freiburg, Germany.
Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany.
Vaccines (Basel). 2023 Jan 30;11(2):309. doi: 10.3390/vaccines11020309.
Acute neurologic complications from Varicella-Zoster-Virus reactivation occur in both immunocompromised and immunocompetent patients. In this report, we describe a case of a previously healthy immunocompetent boy who had received two doses of varicella vaccine at 1 and 4 years. At the age of 12 he developed acute aseptic meningitis caused by vaccine-type varicella-zoster-virus without concomitant skin eruptions. VZV-vaccine strain DNA was detected in the cerebrospinal fluid. The patient made a full recovery after receiving intravenous acyclovir therapy. This disease course documents another case of a VZV vaccine-associated meningitis without development of a rash, i.e., a form of VZV infection manifesting as "zoster sine herpete".
水痘带状疱疹病毒再激活引起的急性神经系统并发症在免疫功能低下和免疫功能正常的患者中均有发生。在本报告中，我们描述了一例既往健康的免疫功能正常男孩的病例，该男孩在1岁和4岁时接种了两剂水痘疫苗。12岁时，他患上了由疫苗型水痘带状疱疹病毒引起的急性无菌性脑膜炎，且没有伴随皮疹。在脑脊液中检测到VZV疫苗株DNA。患者在接受静脉注射阿昔洛韦治疗后完全康复。该病程记录了另一例与VZV疫苗相关的脑膜炎病例，且未出现皮疹，即一种表现为“无疱疹的带状疱疹”的VZV感染形式。
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