Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.
Department of Medicine, Geriatrics and Emergency Medicine, Region Västra Götaland, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.
Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296231158368. doi: 10.1177/10760296231158368.
Cancer is a risk factor for venous thromboembolism (VTE). We aimed to define sex-specific risk of preceding cancer in patients with a first-time VTE by conducting a nationwide Swedish registry-based study including 298 172 patients with VTE and 1 185 079 matched controls. This included 44 685 patients with a diagnosis of cancer at/or within 1 year before a VTE diagnosis. Female patients with VTE had a higher multivariable adjusted odds ratios of preceding cancer than male patients with VTE (5.5 [99% confidence interval 5.4-5.7] vs 3.9 [3.8-4.0]). The highest risk of cancer in patients with VTE were found for pancreatic cancer (women: 19.6 [15.8-24.4]; men: 17.2 [13.7-21.6]) and brain cancer (women: 17.4 [12.9-23.4]; men: 17.5 [13.8-22.2]). Weak associations were seen between VTE and bladder/urothelial cancer (women: 1.31 [1.12-1.53]; men: 1.34 [1.23-1.47]), prostate cancer (men: 2.17 [2.07-2.27]), malignant melanoma (women: 2.51 [2.07-3.05]; men: 2.67 [2.23-3.18]), and kidney cancer (women: 3.20 [2.49-4.11]; men: 3.33 [2.79-4.07]). In conclusion, associations with VTE were weak for bladder/urothelial cancer and kidney cancer, and strong for pancreatic, brain, and biliary cancers.
癌症是静脉血栓栓塞症（VTE）的一个风险因素。我们旨在通过一项全国性的瑞典登记处研究来定义首次 VTE 患者中先前癌症的性别特异性风险，该研究纳入了 298172 例 VTE 患者和 1185079 例匹配对照。其中包括 44685 例在 VTE 诊断前或前 1 年内诊断出癌症的患者。与男性 VTE 患者相比，女性 VTE 患者的先前癌症多变量调整比值比更高（5.5 [99%置信区间 5.4-5.7] vs 3.9 [3.8-4.0]）。VTE 患者中癌症风险最高的是胰腺癌（女性：19.6 [15.8-24.4]；男性：17.2 [13.7-21.6]）和脑癌（女性：17.4 [12.9-23.4]；男性：17.5 [13.8-22.2]）。VTE 与膀胱癌/尿路上皮癌（女性：1.31 [1.12-1.53]；男性：1.34 [1.23-1.47]）、前列腺癌（男性：2.17 [2.07-2.27]）、恶性黑色素瘤（女性：2.51 [2.07-3.05]；男性：2.67 [2.23-3.18]）和肾癌（女性：3.20 [2.49-4.11]；男性：3.33 [2.79-4.07]）之间的相关性较弱。总之，膀胱癌/尿路上皮癌和肾癌与 VTE 的相关性较弱，而胰腺癌、脑癌和胆道癌的相关性较强。
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