He Changhuai, Chu Jie, Li Yiqing, Dang Yiping, Xue Kaming, Cai Chuanqi
Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.
Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Clin Appl Thromb Hemost. 2024 Jan-Dec;30:10760296241305108. doi: 10.1177/10760296241305108.
This research aims to reassess women's risk of venous thromboembolism (VTE) events. We conducted an in-depth analysis of the environmental risk factors associated with VTE and their interactions with gender while also exploring the genetic underpinnings of the disease. VTE is identified as a multifactorial condition influenced by a combination of genetic, non-predisposing, and predisposing environmental factors. We further investigated the genetic basis of VTE, focusing on the identification and analysis of risk loci, as well as gene interaction networks and genetic analyses, which offer significant insights into the pathogenesis of VTE. Recognizing the critical role of gender in assessing VTE risk and developing prevention strategies, this research underscores the necessity of adopting an integrated perspective that accounts for individual vulnerabilities at both genetic and environmental levels to formulate effective preventive measures.
本研究旨在重新评估女性发生静脉血栓栓塞（VTE）事件的风险。我们对与VTE相关的环境风险因素及其与性别的相互作用进行了深入分析，同时也探索了该疾病的遗传基础。VTE被确定为一种受遗传、非易感性和易感性环境因素综合影响的多因素疾病。我们进一步研究了VTE的遗传基础，重点是风险位点的识别与分析，以及基因相互作用网络和遗传分析，这些为深入了解VTE的发病机制提供了重要见解。鉴于性别在评估VTE风险和制定预防策略中的关键作用，本研究强调有必要采取综合视角，在遗传和环境层面考虑个体易感性，以制定有效的预防措施。
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