Azienda Sanitaria Universitaria Giuliano Isontina, ASUGI, SSD Breast Unit, Cattinara Hospital, Strada di Fiume 447, 34129, Trieste, Italy.
Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Via Loredan, 18, 35131, Padua, Italy.
Sci Rep. 2021 Jun 2;11(1):11639. doi: 10.1038/s41598-021-91131-4.
Male breast cancer (MBC) is a rare disease. The few studies on MBC reported conflicting data regarding survival outcomes compared to women. This study has two objectives: to describe the characteristics of a single-cohort of MBC and to compare overall survival (OS) and disease-free survival (DFS) between men and women using the propensity score matching (PSM) analysis. We considered MBC patients (n = 40) diagnosed between January 2004 and May 2019. Clinical, pathological, oncological and follow-up data were analyzed. Univariate analysis was performed to determine the prognostic factors on OS and DFS for MBC. We selected female patients with BC (n = 2678). To minimize the effect of the imbalance of the prognostic factors between the two cohorts, the PSM method (1:3 ratio) was applied and differences in survival between the two groups were assessed. The average age of MBC patients was 73 years. The 5-year OS and DFS rates were 76.7% and 72.2% respectively. The prognostic factors that significantly influenced OS and DFS were tumor size and lymph node status. After the PSM, 5 year-OS was similar between MBC and FBC (72.9% vs 72.3%, p = 0.70) while we found a worse DFS for MBC (72.2% vs 91.4%, p = 0.03). Our data confirmed previous reported MBC characteristics: we found a higher risk of recurrence in MBC compared to FMC but similar OS. MBC and FMC are different entities and studies are needed to understand its epidemiology and guide its management.
男性乳腺癌（MBC）是一种罕见的疾病。少数关于 MBC 的研究报告了与女性相比，生存结果的数据存在矛盾。本研究有两个目的：描述单一队列的 MBC 的特征，并使用倾向评分匹配（PSM）分析比较男性和女性的总生存期（OS）和无病生存期（DFS）。我们考虑了 2004 年 1 月至 2019 年 5 月期间诊断的 MBC 患者（n=40）。分析了临床、病理、肿瘤学和随访数据。进行了单因素分析，以确定 MBC 患者 OS 和 DFS 的预后因素。我们选择了女性 BC 患者（n=2678）。为了最小化两组之间预后因素不平衡的影响，应用了 PSM 方法（1:3 比例），并评估了两组之间的生存差异。MBC 患者的平均年龄为 73 岁。5 年 OS 和 DFS 率分别为 76.7%和 72.2%。显著影响 OS 和 DFS 的预后因素是肿瘤大小和淋巴结状态。在 PSM 后，MBC 和 FBC 的 5 年 OS 相似（72.9% vs 72.3%，p=0.70），而我们发现 MBC 的 DFS 较差（72.2% vs 91.4%，p=0.03）。我们的数据证实了之前报道的 MBC 特征：与 FMC 相比，MBC 复发风险更高，但 OS 相似。MBC 和 FMC 是不同的实体，需要进行研究以了解其流行病学并指导其管理。
