人类原藻病：巴西东北部的一例病例报告。
Human protothecosis: A case report in northeastern Brazil.
作者信息
Santos Daniel Wagner de Castro Lima, Magalhaes Diniz Yankee Costa, Silva Raimunda Ribeiro da, Marques Sirlei Garcia, Bomfim Maria Rosa Quaresma, de Azevedo Conceição de Maria Pedrozo E Silva
机构信息
Instituto D'Or de Pesquisa e Ensino (IDOR), Brazil.
Hospital Universitário da Universidade Federal do Maranhão, Ebserh- HUUFMA, Brazil.
出版信息
Med Mycol Case Rep. 2023 Feb 14;40:1-4. doi: 10.1016/j.mmcr.2023.02.003. eCollection 2023 Jun.
We describe a case of extensive human cutaneous protothecosis in the northeastern of Brazil. The diagnosis was made through histopathological examination of skin samples and culturing on Sabouraud dextrose agar, with identification through mass spectrometry. Treatment with itraconazole failed and was switched to liposomal amphotericin followed by voriconazole with clinical cure. Prothotecosis should be a diagnostic hypothesis when there are skin lesions after trauma, specially in situations of atypical evolution.
我们描述了一例发生在巴西东北部的广泛皮肤原藻病病例。诊断通过皮肤样本的组织病理学检查以及在沙氏葡萄糖琼脂上培养，并通过质谱鉴定。伊曲康唑治疗失败，随后改用脂质体两性霉素，之后换用伏立康唑，最终临床治愈。当外伤后出现皮肤病变时，尤其是在非典型演变的情况下，原藻病应作为一个诊断假设。
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