Than Win Hlaing, Chan Gordon Chun-Kau, Kwan Bonnie Ching-Ha, Lai Ka-Bik, Chan Ronald Cheong-Kin, Teoh Jeromy Yuen Chun, Ng Jack Kit-Chung, Fung Winston Wing-Shing, Chow Kai-Ming, Cheng Phyllis Mei-Shan, Li Philip Kam-Tao, Szeto Cheuk-Chun
Carol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Li Ka Shing Institute of Health Sciences (LiHS), Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Kidney Med. 2023 Jan 9;5(3):100598. doi: 10.1016/j.xkme.2023.100598. eCollection 2023 Mar.
RATIONALE & OBJECTIVE: Omentin-1 is an adipokine with anti-inflammatory and cardioprotective properties. The objective of this study was to determine the prognostic role of plasma omentin-1 levels in incident peritoneal dialysis (PD) patients.
Retrospective analysis of prospective cohort.
SETTING & PARTICIPANTS: 152 incident PD patients.
Plasma omentin-1 level, adipose tissue omentin-1 messenger RNA (mRNA) expression.
Patient survival, technique survival, hospital admission, and duration of stay.
Time-to-event survival analyses; linear regression for hospitalization.
The mean age was 58.4 ± 11.7 years; 102 were men, and 92 had diabetes. There was no significant correlation between plasma omentin-1 level and its adipose tissue mRNA expression. A higher plasma omentin-1 level quartile was not associated with patient survival ( = 0.92) or technique survival ( = 0.83) but had a modest correlation with a lower number of hospital admissions ( = 0.07) and shorter duration of hospital stay ( = 0.04). In adjusted models using multivariable linear regression, a higher plasma omentin-1 level quartile remained significantly associated with fewer hospital admissions (β, -0.13; 95% CI, -0.26 to -0.002; = 0.05) and shorter hospitalization duration (β, -0.20; 95% CI, -0.38 to -0.02; = 0.03).
Observational study with baseline measures only.
Plasma omentin-1 level was not associated with patient survival, technique survival, or peritonitis, but higher plasma omentin-1 levels were associated with fewer hospital admissions and shorter duration of hospitalization among incident PD patients.
网膜素-1是一种具有抗炎和心脏保护特性的脂肪因子。本研究的目的是确定血浆网膜素-1水平在新发腹膜透析（PD）患者中的预后作用。
对前瞻性队列进行回顾性分析。
152例新发PD患者。
血浆网膜素-1水平、脂肪组织网膜素-1信使核糖核酸（mRNA）表达。
患者生存率、技术生存率、住院情况及住院时间。
事件发生时间生存分析；住院情况的线性回归分析。
平均年龄为58.4±11.7岁；男性102例，糖尿病患者92例。血浆网膜素-1水平与其脂肪组织mRNA表达之间无显著相关性。较高的血浆网膜素-1水平四分位数与患者生存率（P = 0.92）或技术生存率（P = 0.83）无关，但与住院次数较少（P = 0.07）和住院时间较短（P = 0.04）有适度相关性。在使用多变量线性回归的校正模型中，较高的血浆网膜素-1水平四分位数仍与住院次数较少（β，-0.13；95%置信区间，-0.26至-0.002；P = 0.05）和住院时间较短（β，-0.20；95%置信区间，-0.38至-0.02；P = 0.03）显著相关。
仅为有基线测量值的观察性研究。
血浆网膜素-1水平与患者生存率、技术生存率或腹膜炎无关，但在新发PD患者中，较高的血浆网膜素-1水平与住院次数较少和住院时间较短有关。
