Matsuno Takahisa, Mikami Tetuo, Hayashi Hiroyuki, Funahashi Kimihiko, Okazumi Shinichi, Hiruta Nobuyuki, Shibuya Kazutoshi, Igarashi Yoshinori
Division of Gastroenterology and Hepatology, Department of Internal Medicine Toho University Omori Medical Center Tokyo Japan.
Department of Pathology Toho University School of Medicine Tokyo Japan.
JGH Open. 2023 Jan 5;7(2):110-117. doi: 10.1002/jgh3.12859. eCollection 2023 Feb.
The rate of ulcerative colitis (UC)-related colorectal cancer (colitis-associated carcinoma) is increasing. Estrogen receptor (ER) beta expression has been studied separately in patients with sporadic colorectal cancer and those with colitis-associated carcinoma. However, no study has compared the expression in both of these cancer types. The present study aimed to evaluate the relationship between colitis-associated carcinoma and ERs and assess whether the expression of ER beta influences cell proliferation.
This study included 45 surgically operated colitis-associated carcinomas, 43 high-grade dysplasias, 34 low-grade dysplasias, 36 sporadic colorectal cancers, 44 high-grade adenomas, and 34 low-grade adenomas. ER beta expression was evaluated with immunohistochemistry.
Colitis-associated carcinoma showed significantly lower ER beta immunoexpression than sporadic colorectal lesions and high- and low-grade dysplasia. In seven colitis-associated carcinoma harboring both intensity score 3 (strong immunoexpression) and score 1 (weak immunoexpression) areas, the correlation among ER beta intensity, Ki-67, and p21 labeling index was assessed; an area with an ER beta intensity score of 3 showed a higher Ki-67 labeling index than that with score 1. In four out of the seven lesions, p21 labeling index was higher in the area of ER beta score 1 than in that of ER beta score 3.
The data suggest that ER beta expression is an accelerating factor in colorectal tumors. This association may be lower in colitis-associated carcinoma than in sporadic colorectal cancer.
溃疡性结肠炎（UC）相关结直肠癌（结肠炎相关癌）的发病率正在上升。雌激素受体（ER）β的表达已分别在散发性结直肠癌患者和结肠炎相关癌患者中进行了研究。然而，尚无研究对这两种癌症类型中的表达情况进行比较。本研究旨在评估结肠炎相关癌与雌激素受体之间的关系，并评估ERβ的表达是否影响细胞增殖。
本研究纳入了45例手术切除的结肠炎相关癌、43例高级别发育异常、34例低级别发育异常、36例散发性结直肠癌、44例高级别腺瘤和34例低级别腺瘤。采用免疫组织化学法评估ERβ的表达。
结肠炎相关癌的ERβ免疫表达明显低于散发性结直肠病变以及高级别和低级别发育异常。在7例同时存在强度评分为3（强免疫表达）和评分为1（弱免疫表达）区域的结肠炎相关癌中，评估了ERβ强度、Ki-67和p21标记指数之间的相关性；ERβ强度评分为3的区域显示出比评分为1的区域更高的Ki-67标记指数。在这7个病变中的4个中，ERβ评分为1的区域的p21标记指数高于ERβ评分为3的区域。
数据表明ERβ表达是结直肠肿瘤的一个促进因素。这种关联在结肠炎相关癌中可能低于散发性结直肠癌。
