He Mengxue, Shi Jiachen, Liu Aiyang, Xu Yong-Jiang, Liu Yuanfa
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, 214122 Wuxi, China.
Mol Omics. 2023 May 9;19(4):330-339. doi: 10.1039/d2mo00284a.
Antibiotics are useful for treating infections caused by bacteria, but they have negative effects on the host body. The goal of this study was to determine whether antibiotics alter the metabolic phenotype of the host. We found that taking antibiotics reduced the diversity and richness of gut microbiota and affected the composition of the microbiome, which in turn altered the metabolic profiles of plasma and fecal samples. Additionally, plasma and fecal metabolites and gut microbiota genera showed a significant association. The most significant pathways related to the gut dysbiosis induced by antibiotics including purine, pentose, and glucuronate metabolism, histidine, ascorbate and alternate, lysine degradation, and fatty acid biosynthesis. The relationship between gut microbiota and altered metabolites of plasma and feces provides information about bacterial action, which is useful for designing new microbiota-based disease prevention and treatment interventions.
抗生素对治疗由细菌引起的感染很有用，但它们对宿主身体有负面影响。本研究的目的是确定抗生素是否会改变宿主的代谢表型。我们发现服用抗生素会降低肠道微生物群的多样性和丰富度，并影响微生物组的组成，进而改变血浆和粪便样本的代谢谱。此外，血浆和粪便代谢物与肠道微生物群属之间存在显著关联。与抗生素诱导的肠道生态失调最相关的途径包括嘌呤、戊糖和葡萄糖醛酸代谢、组氨酸、抗坏血酸及替代途径、赖氨酸降解和脂肪酸生物合成。肠道微生物群与血浆和粪便代谢物改变之间的关系提供了有关细菌作用的信息，这对于设计新的基于微生物群的疾病预防和治疗干预措施很有用。
