Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, U.S.A.
Yale School of Medicine, New Haven, Connecticut, U.S.A.
Ophthalmic Plast Reconstr Surg. 2023;39(3):e78-e81. doi: 10.1097/IOP.0000000000002338. Epub 2023 Feb 28.
Ocular manifestations in chronic lymphocytic leukemia (CLL) have been reported in 30% to 40% of patients and may be a result of direct tissue infiltration, concomitant blood dyscrasias, or a result of therapeutic intervention. Leukemia cutis, defined as infiltration of the epidermis or dermis by neoplastic lymphocytes, is rare. Herein, we present a case report of a patient with leukemia who presented with periorbital edema and ecchymosis. This is the first known case to date of periorbital CLL successfully treated with low-dose radiation therapy (4 Gy in 2 fractions). Clinicians should be aware of the possibility of ocular involvement from CLL, given the importance of prompt diagnosis and treatment.
慢性淋巴细胞白血病（CLL）患者中有 30%至 40%会出现眼部表现，其可能是由于直接的组织浸润、同时存在的血液系统异常或治疗干预的结果。白血病皮肤浸润是指肿瘤淋巴细胞浸润表皮或真皮，较为罕见。本文报告了一例以眶周水肿和瘀斑为表现的白血病患者。这是迄今为止首例经低剂量放射治疗（4 Gy 分 2 次）成功治疗的眶周 CLL 病例。鉴于及时诊断和治疗的重要性，临床医生应该意识到 CLL 可能导致眼部受累的可能性。
