Fried Lauren J, Criscito Maressa C, Stevenson Mary L, Pomeranz Miriam K
The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York City, NY, USA.
Int J Dermatol. 2022 May;61(5):519-531. doi: 10.1111/ijd.15629. Epub 2021 May 5.
B-cell chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the United States, and its diagnosis can have many dermatologic implications. For one, the cutaneous manifestations of CLL include several entities, most notably leukemia cutis, eosinophilic dermatosis of hematologic malignancy, and a heightened risk of skin infections. Additionally, CLL patients are at an increased risk of secondary malignancies, most commonly of the skin. Furthermore, a number of commonly utilized treatments for CLL have cutaneous implications which should be considered in the interdisciplinary management of CLL patients. In this review, we will provide an update on the diverse cutaneous manifestations of CLL and CLL-directed therapies in order to help guide dermatologic management of this increasingly prevalent patient population.
B细胞慢性淋巴细胞白血病（CLL）是美国最常见的白血病，其诊断可能会对皮肤病学产生诸多影响。一方面，CLL的皮肤表现包括多种病症，最显著的是白血病性皮肤浸润、血液系统恶性肿瘤的嗜酸性皮肤病以及皮肤感染风险增加。此外，CLL患者发生继发性恶性肿瘤的风险增加，最常见于皮肤。再者，一些常用于治疗CLL的方法会对皮肤产生影响，在CLL患者的多学科管理中应予以考虑。在本综述中，我们将提供有关CLL各种皮肤表现及针对CLL的治疗方法的最新信息，以帮助指导对这一日益普遍的患者群体的皮肤病学管理。
