Aortic Valve Center, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Heart, Vascular, and Thoracic Institute, Cleveland, OH, USA.
Eur J Cardiothorac Surg. 2023 May 2;63(5). doi: 10.1093/ejcts/ezad057.
OBJECTIVES: Porcelain aorta complicates aortic valve replacement and is an indication for transcatheter approaches. No study has compared surgical and transcatheter valve replacement in the setting of porcelain aorta. We characterize porcelain aorta patients undergoing aortic valve replacement and the association of aortic calcification and outcomes. METHODS: Patients undergoing aortic valve replacement with porcelain aorta were identified. Aortic calcium volume was determined using 3D computed tomography thresholding techniques. Propensity scoring was performed to assess the effect of surgical versus transcatheter approaches. Risk factors for composite major hospital complications (death, stroke and dialysis) were identified using random forest machine learning. RESULTS: From January 2006 to January 2015, 164 patients with porcelain aorta underwent aortic valve replacement [105 (64%) surgical replacement, 59 (36%) transcatheter replacement]. Propensity scoring matched 29 pairs (49% of transcatheter patients). Before matching, 5-year survival was 41% [(43% surgical, 35% transcatheter, P(log-rank) = 0.9]. After matching, mortality for surgical versus transcatheter replacement was 3.4% (n = 1) vs 10% (n = 3), stroke 14% (n = 4) vs 3.4% (n = 1) and dialysis 6.9% (n = 2) versus 11% (n = 3). Matched 5-year survival was 40% after surgical replacement and 29% after transcatheter replacement [P(log-rank) = 0.4]. Total aortic calcium volume was greater in transcatheter than surgical patients [18 (8.0) vs 17 (7.7) ml] and was associated with more major hospital complications after either approach. CONCLUSIONS: Surgical and transcatheter approaches are complementary options for aortic stenosis with porcelain aorta. Surgical valve replacement remains an effective treatment for patients requiring concomitant procedures. Quantifying aortic calcium volume is a helpful risk predictor in all patients with porcelain aorta.
目的:主动脉瓣置换术中并发主动脉瓷化是经导管治疗的指征。目前尚没有研究比较过在主动脉瓣瓷化患者中进行外科手术和经导管瓣膜置换术的效果。本研究旨在描述主动脉瓣置换术中并发主动脉瓷化的患者特征,以及主动脉钙化与结局之间的相关性。
方法:我们确定了在主动脉瓣置换术中并发主动脉瓷化的患者。使用三维计算机断层扫描阈值技术确定主动脉钙体积。采用倾向性评分评估外科手术与经导管方法的效果。使用随机森林机器学习方法确定复合主要医院并发症(死亡、卒中和透析)的危险因素。
结果:从 2006 年 1 月至 2015 年 1 月,164 例主动脉瓣置换术患者并发主动脉瓷化[105 例(64%)接受外科置换,59 例(36%)接受经导管置换]。倾向性评分匹配了 29 对患者(经导管治疗患者的 49%)。匹配前,外科手术组和经导管治疗组的 5 年生存率分别为 41%[43%(外科手术组),35%(经导管治疗组),P(对数秩检验)=0.9]。匹配后,外科手术组和经导管治疗组的死亡率分别为 3.4%(n=1)和 10%(n=3),卒中发生率分别为 14%(n=4)和 3.4%(n=1),透析发生率分别为 6.9%(n=2)和 11%(n=3)。外科手术组和经导管治疗组的 5 年生存率分别为 40%和 29%[P(对数秩检验)=0.4]。经导管治疗组的总主动脉钙体积大于外科手术组[18(8.0)ml 比 17(7.7)ml],且两种方法治疗后主要医院并发症的发生率均较高。
结论:对于主动脉瓣狭窄并发主动脉瓷化患者,外科手术和经导管治疗是互补的选择。对于需要同时进行其他手术的患者,外科瓣膜置换术仍然是一种有效的治疗方法。量化主动脉钙体积是所有主动脉瓣瓷化患者的一种有用的风险预测指标。
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