Ghaffarlou Mohammadreza, İlk Sedef, Rahimi Hossein, Danafar Hossein, Barsbay Murat, Sharafi Ali
Department of Chemistry, Hacettepe University, Beytepe, Ankara, 06800, Turkey.
Faculty of Medicine, Department of Immunology, Niğde Ömer Halisdemir University, Niğde, 51240, Turkey.
Nanomedicine (Lond). 2022 Dec;17(28):2145-2155. doi: 10.2217/nnm-2022-0203. Epub 2023 Feb 28.
Quorum sensing (QS) is a density-dependent chemical process of cell-to-cell communication in which certain signals are activated, leading to the coordination of pathogenic behaviors and the regulation of virulence in bacteria. Inhibition of QS can prevent biofilm formation and reduce virulence behaviors of bacteria. Herein, bovine serum albumin (BSA)-coated silver nanoparticles (NPs) (Ag-AgS@BSA NPs) were synthesized and studied as an anti-QS agent. Ag-AgS NPs prepared through a BSA-mediated biomineralization process under ambient aqueous conditions and their physicochemical properties were characterized. The anti-QS activity of the resulting BSA-coated NPs (Ag-AgS@BSA NPs) was investigated for the first time. The result confirmed the potential of Ag-AgS@BSA NPs as novel and useful therapeutic tools for antibacterial purposes.
群体感应（QS）是一种细胞间通讯的密度依赖性化学过程，其中某些信号被激活，导致细菌致病行为的协调和毒力的调节。抑制群体感应可以防止生物膜形成并降低细菌的毒力行为。在此，合成了牛血清白蛋白（BSA）包覆的银纳米颗粒（NPs）（Ag-AgS@BSA NPs）并将其作为一种群体感应抑制剂进行研究。通过在环境水条件下的BSA介导的生物矿化过程制备了Ag-AgS NPs，并对其物理化学性质进行了表征。首次研究了所得的BSA包覆的NPs（Ag-AgS@BSA NPs）的群体感应抑制活性。结果证实了Ag-AgS@BSA NPs作为新型且有用的抗菌治疗工具的潜力。
