吲哚美辛与布洛芬的对比研究。

A comparative study of indomethacin and ibuprofen.

作者信息

McArthur A W, Ferry D G, Palmer D G

出版信息

Med J Aust. 1979 Jan 13;1(1):25-7. doi: 10.5694/j.1326-5377.1979.tb111959.x.

DOI:10.5694/j.1326-5377.1979.tb111959.x

Abstract

In a double blind trial with 20 patients ibuprofen 1600 mg daily and indomethacin 100 mg daily were shown to be of comparable efficacy in the short-term treatment of rheumatoid arthritis. Reported side effects were similar, but a slightly greater incidence of gastric irritation was noted with indomethacin necessitating withdrawal of one patient from the trial. The serum concentrations for indomethacin and ibuprofen were determined for four hours after the last dose. Peak concentrations of both drugs occurred within two hours. Five of the seven patients considered to have comparable serum concentrations of both drugs demonstrated a preference for indomethacin.

摘要

在一项针对20名患者的双盲试验中，结果表明，每日服用1600毫克布洛芬和每日服用100毫克吲哚美辛在类风湿性关节炎的短期治疗中疗效相当。报告的副作用相似，但服用吲哚美辛时胃刺激的发生率略高，导致一名患者退出试验。在最后一剂药物服用后四小时测定吲哚美辛和布洛芬的血清浓度。两种药物的峰值浓度均在两小时内出现。在七名被认为两种药物血清浓度相当的患者中，有五名表现出对吲哚美辛的偏好。