布洛芬和吲哚美辛用于类风湿性关节炎的长期双盲临床试验。
A long-term double-blind clinical trial of ibuprofen and indomethacin in rheumatoid arthritis.
作者信息
Royer G L, Moxley T E, Hearron M S, Miyara A, Shenker B M
机构信息
Domestic Pharmaceutical Medical Affairs, Upjohn Company, Kalamazoo, Michigan.
出版信息
J Int Med Res. 1975;3(3):158-71. doi: 10.1177/030006057500300304.
PMID:162672
Abstract
Two-hundred and eighteen individuals with rheumatoid arthritis were randomly assigned to six months treatment with ibuprofen (900-1800 mg/day) or indomethacin (75-150 mg/day). The drugs were equally effective in the treatment of rheumatoid arthritis while the incidence of indomethacin side-effects was 1.5 times greater than the incidence of ibuprofen side-effects.
摘要
218名类风湿性关节炎患者被随机分配接受为期6个月的布洛芬（900 - 1800毫克/天）或吲哚美辛（75 - 150毫克/天）治疗。两种药物在治疗类风湿性关节炎方面同样有效，但吲哚美辛副作用的发生率比布洛芬副作用的发生率高1.5倍。
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