Kaiser Permanente Northern California, Vaccine Study Center, Oakland, CA, USA.
Yale University, Institute for Global Health, New Haven, CT, USA.
Nat Commun. 2023 Feb 28;14(1):894. doi: 10.1038/s41467-023-36547-4.
We examined the effectiveness of maternal vaccination against SARS-CoV-2 infection in 30,311 infants born at Kaiser Permanente Northern California from December 15, 2020, to May 31, 2022. Using Cox regression, the effectiveness of ≥2 doses of COVID-19 vaccine received during pregnancy was 84% (95% confidence interval [CI]: 66, 93), 62% (CI: 39, 77) and 56% (CI: 34,71) during months 0-2, 0-4 and 0- 6 of a child's life, respectively, in the Delta variant period. In the Omicron variant period, the effectiveness of maternal vaccination in these three age intervals was 21% (CI: -21,48), 14% (CI: -9,32) and 13% (CI: -3,26), respectively. Over the entire study period, the incidence of hospitalization for COVID-19 was lower during the first 6 months of life among infants of vaccinated mothers compared with infants of unvaccinated mothers (21/100,000 person-years vs. 100/100,000 person-years). Maternal vaccination was protective, but protection was lower during Omicron than during Delta. Protection during both periods decreased as infants aged.
我们研究了在 2020 年 12 月 15 日至 2022 年 5 月 31 日期间在 Kaiser Permanente 北加州出生的 30311 名婴儿中，母亲接种 SARS-CoV-2 疫苗对感染的有效性。使用 Cox 回归，在 Delta 变异株流行期间，怀孕期间接种≥2 剂 COVID-19 疫苗的有效性分别为 84%（95%置信区间：66,93）、62%（39,77）和 56%（34,71）。在 Omicron 变异株流行期间，在这三个年龄间隔内，母亲接种疫苗的有效性分别为 21%（CI：-21,48）、14%（CI：-9,32）和 13%（CI：-3,26）。在整个研究期间，与未接种疫苗的母亲所生婴儿相比，接种疫苗的母亲所生婴儿在生命的前 6 个月因 COVID-19 住院的发生率较低（21/100,000 人年 vs. 100/100,000 人年）。母亲接种疫苗具有保护作用，但在 Omicron 期间的保护作用低于 Delta。在这两个时期，随着婴儿年龄的增长，保护作用都有所下降。
