Department of Gastroenterology, Tianjin Union Medical Center, Tianjin, China.
Department of Pathology, Tianjin Union Medical Center, Tianjin, China.
IET Syst Biol. 2023 Apr;17(2):83-94. doi: 10.1049/syb2.12062. Epub 2023 Feb 28.
The link between family with sequence similarity 99 member A (FAM99A), a type of long non-coding RNA, and tumourigenesis remains ambiguous. Therefore, in this study, the authors conducted an expression profile analysis of FAM99A based on 33 types of cancer within The Cancer Genome Atlas project. The expression profile data revealed low expression levels of FAM99A in hepatocellular carcinoma, cholangiocarcinoma, and testicular germ cell tumour tissues than in the normal control tissues. Survival analysis indicated a correlation between low FAM99A expression and worse survival outcome in patients with hepatic cancer. Further investigation revealed the possible implication of DNA methylation, but not copy number variation, in FAM99A-associated hepatic tumourigenesis. The authors also identified a set of differentially expressed genes between patients with hepatic cancer and negative controls, which were found to be related to biochemical metabolism or the cell cycle. Additionally, FAM99A expression may be associated with the infiltration status of several immune cells, such as dendritic cells, natural killer cells, and neutrophils. Overall, FAM99A may function as a prognostic marker that is potentially associated with DNA methylation, immune cell infiltration, and biochemical metabolism in hepatic cancer.
家族性与序列相似性 99 成员 A（FAM99A）是一种长链非编码 RNA，其与肿瘤发生之间的联系尚不清楚。因此，在本研究中，作者基于癌症基因组图谱计划中的 33 种癌症类型，对 FAM99A 的表达谱进行了分析。表达谱数据显示，在肝癌、胆管癌和睾丸生殖细胞肿瘤组织中 FAM99A 的表达水平低于正常对照组织。生存分析表明，低表达 FAM99A 与肝癌患者的生存结局较差相关。进一步的研究揭示了 DNA 甲基化而不是拷贝数变异在 FAM99A 相关肝肿瘤发生中的可能作用。作者还鉴定了一组肝癌患者与阴性对照之间差异表达的基因，这些基因与生化代谢或细胞周期有关。此外，FAM99A 的表达可能与几种免疫细胞（如树突状细胞、自然杀伤细胞和中性粒细胞）的浸润状态有关。总的来说，FAM99A 可能作为一个预后标志物，与肝癌中的 DNA 甲基化、免疫细胞浸润和生化代谢有关。
