• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

托吡酯用于遗传性脊髓小脑共济失调患者的试验。

A trial of topiramate for patients with hereditary spinocerebellar ataxia.

作者信息

Miura Shiroh, Sawada Ryusuke, Yorita Akiko, Kida Hiroshi, Kamada Takashi, Yamanishi Yoshihiro

机构信息

Department of Neurology and Geriatric Medicine Ehime University Graduate School of Medicine Toon Ehime Japan.

Department of Pharmacology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kita-ku Okayama Japan.

出版信息

Clin Case Rep. 2023 Feb 26;11(2):e6980. doi: 10.1002/ccr3.6980. eCollection 2023 Feb.

DOI:10.1002/ccr3.6980
PMID:36855409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9968455/
Abstract

In an open pilot trial, six patients with various hereditary forms of spinocerebellar ataxia (SCA) were assigned to topiramate (50 mg/day) for 24 weeks. Four patients completed the protocol without adverse events. Of these four patients, topiramate was effective for three patients. Some patients with SCA could respond to treatment with topiramate.

摘要

在一项开放性试验中，6例患有各种遗传性脊髓小脑共济失调（SCA）的患者被分配接受托吡酯治疗（50毫克/天），为期24周。4例患者完成了方案且无不良事件发生。在这4例患者中，托吡酯对3例患者有效。一些SCA患者可能对托吡酯治疗有反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813b/9968455/f898b4d690d8/CCR3-11-e6980-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813b/9968455/f898b4d690d8/CCR3-11-e6980-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813b/9968455/f898b4d690d8/CCR3-11-e6980-g002.jpg

相似文献

1
A trial of topiramate for patients with hereditary spinocerebellar ataxia.托吡酯用于遗传性脊髓小脑共济失调患者的试验。
Clin Case Rep. 2023 Feb 26;11(2):e6980. doi: 10.1002/ccr3.6980. eCollection 2023 Feb.
2
Frequency of SCA1, SCA2, SCA3/MJD, SCA6, SCA7, and DRPLA CAG trinucleotide repeat expansion in patients with hereditary spinocerebellar ataxia from Chinese kindreds.中国家系遗传性脊髓小脑共济失调患者中SCA1、SCA2、SCA3/MJD、SCA6、SCA7和DRPLA CAG三核苷酸重复扩增的频率
Arch Neurol. 2000 Apr;57(4):540-4. doi: 10.1001/archneur.57.4.540.
3
Gait characteristics and clinical relevance of hereditary spinocerebellar ataxia on deep learning.深度学习中遗传性脊髓小脑共济失调的步态特征及临床相关性。
Artif Intell Med. 2020 Mar;103:101794. doi: 10.1016/j.artmed.2020.101794. Epub 2020 Jan 7.
4
Frequency of spinocerebellar ataxia types 1,2,3,6,7 and dentatorubral pallidoluysian atrophy mutations in Korean patients with spinocerebellar ataxia.
J Neurol. 1999 Mar;246(3):207-10. doi: 10.1007/s004150050335.
5
Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families.遗传性脊髓小脑共济失调的分子遗传学：225个意大利家庭中脊髓小脑共济失调基因的突变分析及CAG/CTG重复序列扩增检测
Arch Neurol. 2004 May;61(5):727-33. doi: 10.1001/archneur.61.5.727.
6
Effects of acetyl-DL-leucine on cerebellar ataxia (ALCAT trial): study protocol for a multicenter, multinational, randomized, double-blind, placebo-controlled, crossover phase III trial.乙酰-DL-亮氨酸对小脑共济失调的影响（ALCAT试验）：一项多中心、跨国、随机、双盲、安慰剂对照、交叉III期试验的研究方案。
BMC Neurol. 2017 Jan 10;17(1):7. doi: 10.1186/s12883-016-0786-x.
7
Evaluation of Various Movement Disorders in Patients of Genetically Proven Spinocerebellar Ataxia: A Study from a Tertiary Care Center in Northern India.经基因确诊的脊髓小脑共济失调患者各种运动障碍的评估：来自印度北部一家三级护理中心的研究
Ann Indian Acad Neurol. 2018 Jan-Mar;21(1):24-28. doi: 10.4103/aian.AIAN_266_17.
8
Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes.弗里德赖希共济失调及其他遗传性共济失调综合征言语障碍的治疗。
Cochrane Database Syst Rev. 2014 Oct 28;2014(10):CD008953. doi: 10.1002/14651858.CD008953.pub2.
9
Repetitive Transcranial Magnetic Stimulation in Spinocerebellar Ataxia: A Pilot Randomized Controlled Trial.重复经颅磁刺激治疗脊髓小脑共济失调：一项初步随机对照试验
Front Neurol. 2019 Feb 12;10:73. doi: 10.3389/fneur.2019.00073. eCollection 2019.
10
Phenotypic and Genotypic Analysis of Hereditary Ataxia Patients in Sakarya City, Turkey.土耳其萨卡里亚市遗传性共济失调患者的表型和基因型分析。
Noro Psikiyatr Ars. 2018 Jul 11;56(2):106-109. doi: 10.5152/npa.2017.20525. eCollection 2019 Jun.

本文引用的文献

1
Episodic Vestibulocerebellar Ataxia Associated with a Missense Variant.与错义变异相关的发作性前庭小脑共济失调
Case Rep Neurol. 2021 Jun 11;13(2):347-354. doi: 10.1159/000515974. eCollection 2021 May-Aug.
2
Spinocerebellar ataxia 27 with a novel nonsense variant (Lys177X) in FGF14.伴有成纤维细胞生长因子14（FGF14）中新型无义变异（Lys177X）的脊髓小脑共济失调27型
Eur J Med Genet. 2019 Mar;62(3):172-176. doi: 10.1016/j.ejmg.2018.07.005. Epub 2018 Jul 11.
3
Cellular and circuit mechanisms underlying spinocerebellar ataxias.脊髓小脑共济失调的细胞和环路机制
J Physiol. 2016 Aug 15;594(16):4653-60. doi: 10.1113/JP271897. Epub 2016 Jun 12.
4
Target-Based Drug Repositioning Using Large-Scale Chemical-Protein Interactome Data.基于大规模化学-蛋白质互作组学数据的靶向药物再定位。
J Chem Inf Model. 2015 Dec 28;55(12):2717-30. doi: 10.1021/acs.jcim.5b00330. Epub 2015 Dec 1.
5
Systematic drug repositioning for a wide range of diseases with integrative analyses of phenotypic and molecular data.通过对表型和分子数据的综合分析，对多种疾病进行系统性药物重新定位。
J Chem Inf Model. 2015 Feb 23;55(2):446-59. doi: 10.1021/ci500670q. Epub 2015 Jan 28.
6
EFNS/ENS Consensus on the diagnosis and management of chronic ataxias in adulthood.EFNS/ENS 成人慢性共济失调诊断和管理共识。
Eur J Neurol. 2014 Apr;21(4):552-62. doi: 10.1111/ene.12341. Epub 2014 Jan 13.
7
Drug repositioning: a machine-learning approach through data integration.药物重定位：一种通过数据集成的机器学习方法。
J Cheminform. 2013 Jun 22;5(1):30. doi: 10.1186/1758-2946-5-30.
8
Challenges and opportunities of drug repositioning.药物重定位的挑战与机遇。
Trends Pharmacol Sci. 2013 May;34(5):267-72. doi: 10.1016/j.tips.2013.03.004. Epub 2013 Apr 12.
9
Hereditary ataxias: overview.遗传性共济失调：概述。
Genet Med. 2013 Sep;15(9):673-83. doi: 10.1038/gim.2013.28. Epub 2013 Mar 28.
10
A case of nocturnal frontal lobe epilepsy in a patient with spinocerebellar ataxia type 17.
Seizure. 2012 Dec;21(10):805-6. doi: 10.1016/j.seizure.2012.08.006. Epub 2012 Sep 19.